Effects of Hyperbaric Oxygen Therapy on Tumor Growth in Murine Model of PC-3 Prostate Cancer Cell Line

被引:11
作者
Tang, Hao [1 ]
Sun, Yinghao [1 ]
Xu, Chuanliang [1 ]
Zhou, Tie [1 ]
Gao, Xu [1 ]
Wang, Linhui [1 ]
机构
[1] Shanghai Changhai Hosp, Dept Urol, Shanghai 200433, Peoples R China
关键词
CARCINOMA; HYPOXIA; CHEMOTHERAPY; METASTASIS; PRESSURE; EXPOSURE; MOUSE; LUNG; MICE;
D O I
10.1016/j.urology.2008.04.057
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
OBJECTIVES To test the hypothesis that hyperbaric oxygen (HBO) has no effect on tumor growth in a murine model of indolent in vivo prostate cancer. HBO means breathing pure (100%) oxygen under increased atmospheric pressure. METHODS Human prostate PC-3 cells were injected into 40 severe combined-immunodeficient mice. They were randomized to undergo 20 sessions of either HBO or normobaric air in standardized conditions and observed for 4 weeks before histologic assessment of any palpable tumors that had developed. The analysis of the developed PC-3 tumors included tumor volume, microvessel density, apoptosis-associated markers (ie, p53, p27), and the proliferative index (Ki-67). RESULTS The exposure to HBO at 2 arm for 20 treatment sessions, which comprised a daily 90-minute session, 5 d/wk, had no effect on the prostate cancer volume (P > .05). No differences were observed in tumor microvessel density, proliferative index, or apoptosis markets compared with the non-HBO group (P > .05). CONCLUSIONS HBO did not have a tumor stimulatory effect on prostate cancer and could potentially be used safely in conjunction with other therapeutic modalities. UROLOGY 73: 205-208, 2009. (C) 2009 Elsevier Inc.
引用
收藏
页码:205 / 208
页数:4
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