Pediatric psoriasis: Evolving perspectives

被引:72
作者
Eichenfield, Lawrence F. [1 ,2 ,3 ]
Paller, Amy S. [4 ,5 ]
Tom, Wynnis L. [1 ,2 ,3 ]
Sugarman, Jeffrey [6 ]
Hebert, Adelaide A. [7 ,8 ]
Friedlander, Sheila Fallon [1 ,2 ,3 ]
Siegfried, Elaine [9 ,10 ]
Silverberg, Nanette [11 ,12 ]
Cordoro, Kelly M. [6 ,13 ]
机构
[1] Univ Calif San Diego, Sch Med, Dept Dermatol, San Diego, CA 92103 USA
[2] Rady Childrens Hosp, San Diego, CA 92123 USA
[3] Univ Calif San Diego, Sch Med, Dept Pediat, San Diego, CA 92103 USA
[4] Northwestern Univ, Dept Dermatol, Feinberg Sch Med, Chicago, IL 60611 USA
[5] Northwestern Univ, Dept Pediat, Feinberg Sch Med, Chicago, IL 60611 USA
[6] Univ Calif San Francisco, Sch Med, Dept Dermatol, San Francisco, CA USA
[7] McGovern Sch Med, Pediat Dermatol, Houston, TX USA
[8] Childrens Mem Hermann Hosp, Houston, TX USA
[9] St Louis Univ, Sch Med, Dept Pediat, Cardinal Glennon Childrens Hosp, St Louis, MO 63104 USA
[10] St Louis Univ, Sch Med, Cardinal Glennon Childrens Hosp, Dept Dermatol, St Louis, MO 63104 USA
[11] Icahn Sch Med Mt Sinai, Dept Dermatol, New York, NY 10029 USA
[12] Icahn Sch Med Mt Sinai, Dept Pediat, New York, NY 10029 USA
[13] Univ Calif San Francisco, Sch Med, Dept Pediat, San Francisco, CA USA
关键词
clinical; disease burden; epidemiology; pediatrics; psoriasis; treatment; QUALITY-OF-LIFE; CLINICAL-FEATURES; PUSTULAR PSORIASIS; ETANERCEPT TREATMENT; CHILDHOOD PSORIASIS; PLAQUE PSORIASIS; ONSET PSORIASIS; RISK-FACTORS; EPIDEMIOLOGY; CHILDREN;
D O I
10.1111/pde.13382
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Background/ObjectivesChildhood-onset psoriasis is a common skin disorder that has recently received increasing attention, particularly because of its significant medical, social, financial, and psychological burdens and its associated comorbidities. With limited data available and lack of standardized management guidelines for pediatric psoriasis, an expert panel desired to provide an updated critical overview and practical guidance for management of the affected population. MethodsA panel of pediatric dermatologists with extensive experience in pediatric psoriasis defined and prioritized a core set of topics, performed an English-language literature review, prepared critical evaluations and presentations of topic areas, and carried out a consensus meeting and follow-up consensus manuscript. ResultsThe summation of evolving perspectives in pediatric psoriasis includes epidemiology and natural history of the disease, precipitating factors and comorbidities, quality of life and burden of disease, clinical features and disease presentation, differential diagnosis, pathogenesis and treatment, including topical, photo, and systemic therapies. ConclusionPediatric psoriasis is an important immune-mediated inflammatory skin disease with potential for significant impact on affected individuals and their caregivers. Current state-of-the-art care is based primarily on experience and expert consensus, but pediatric data are accumulating and therapeutic options are rapidly evolving.
引用
收藏
页码:170 / 181
页数:12
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