Intake of Passiflora edulis leaf extract improves antioxidant and anti-inflammatory status in rats with 2,4,6-trinitrobenzenesulphonic acid induced colitis

被引：40

作者：

Betim Cazarin, Cinthia Bau ^{[1
]}

da Silva, Juliana Kelly ^{[1
]}

Colomeu, Talita Cristina ^{[2
]}

Batista, Angela Giovana ^{[1
]}

Molina Meletti, Laura Maria ^{[3
]}

Rizzato Paschoal, Jonas Augusto ^{[1
]}

Bogusz Junior, Stanislau ^{[4
]}

de Campos Braga, Patricia Aparecida ^{[1
]}

Reyes Reyes, Felix Guillermo ^{[1
]}

Augusto, Fabio ^{[5
]}

de Meirelles, Luciana Rodrigues ^{[2
]}

Zollner, Ricardo de Lima ^{[2
]}

Marostica Junior, Mario Roberto ^{[1
]}

机构：

[1] Univ Estadual Campinas, Sch Food Engn, Sao Paulo, Brazil

[2] Univ Estadual Campinas, Fac Med Sci, Sao Paulo, Brazil

[3] Agron Inst Campinas, Ctr Res & Dev Plant Genet Resources, Campinas, SP, Brazil

[4] Univ Sao Paulo, Inst Chem Sao Carlos IQSC, Sao Paulo, Brazil

[5] Univ Estadual Campinas, Inst Chem, Inst Nacl Ciencia & Tecnol Bioanalit INCTBio, Sao Paulo, Brazil

来源：

JOURNAL OF FUNCTIONAL FOODS | 2015年 / 17卷

基金：

巴西圣保罗研究基金会;

关键词：

Passiflora edulis leaves; Colitis; Oxidative stress; Antioxidant potential; Anti-inflammatory activity; GREEN TEA CONSUMPTION; NF-KAPPA-B; OXIDATIVE STRESS; IN-VITRO; MOUSE MODEL; INFLAMMATION; ISOVITEXIN; PLASMA; LEAVES; POLYPHENOLS;

D O I：

10.1016/j.jff.2015.05.034

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

The antioxidant and anti-inflammatory effects of the aqueous extract of Passiflora edulis leaves, which is a source of vitexin, isovitexin and isoorientin, was investigated in a 2,4,6-trinitrobenzenesulphonic acid induced colitis model. The oral intake of P. edulis extract (1100 mu g mL(-1)) improved significantly (P < 0.05) the endogenous antioxidant status and decreased lipid peroxidation in serum, liver, and colon. The consumption of P. edulis extract decreased the level of pro-inflammatory in colon tissue, especially by reducing IL-1 beta fivefold and TNF-alpha two-fold compared to the control colitis group. The extract of P. edulis leaves possessed therapeutic activity in healthy rats and in TNBS-induced colitis, especially by controlling the oxidative stress and inflammation observed in this disease. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：575 / 586

页数：12

共 51 条

[1] MSE with mass defect filtering for in vitro and in vivo metabolite identification [J].

Bateman, Kevin P. ;

Castro-Perez, Jose ;

Wrona, Mark ;

Shockcor, John P. ;

Yu, Kate ;

Oballa, Renata ;

Nicoll-Griffith, Deborah A. .

RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 2007, 21 (09) :1485-1496

[2] DISRUPTION OF COLONIC ELECTROLYTE TRANSPORT IN EXPERIMENTAL COLITIS [J].

BELL, CJ ;

GALL, DG ;

WALLACE, JL .

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 1995, 268 (04) :G622-G630

[3] The ferric reducing ability of plasma (FRAP) as a measure of ''antioxidant power'': The FRAP assay [J].

Benzie, IFF ;

Strain, JJ .

ANALYTICAL BIOCHEMISTRY, 1996, 239 (01) :70-76

[4]

Bezerra José Antonio Ferreira, 2006, Acta Cir. Bras., V21, P16

[5] Vitexin Inhibits Inflammatory Pain in Mice by Targeting TRPV1, Oxidative Stress, and Cytokines [J].

Borghi, Sergio M. ;

Carvalho, Thacyana T. ;

Staurengo-Ferrari, Larissa ;

Hohmann, Miriam S. N. ;

Pinge-Filho, Phileno ;

Casagrande, Rubia ;

Verri, Waldiceu A., Jr. .

JOURNAL OF NATURAL PRODUCTS, 2013, 76 (06) :1141-1149

[6]

BRADFORD MM, 1976, ANAL BIOCHEM, V72, P248, DOI 10.1016/0003-2697(76)90527-3

[7]

CARLBERG I, 1985, METHOD ENZYMOL, V113, P484

[8] Prostaglandin E2 and SOCS1 have a role in intestinal immune tolerance [J].

Chinen, Takatoshi ;

Komai, Kyoko ;

Muto, Go ;

Morita, Rimpei ;

Inoue, Naoko ;

Yoshida, Hideyuki ;

Sekiya, Takashi ;

Yoshida, Ryoko ;

Nakamura, Kazuhiko ;

Takayanagi, Ryoichi ;

Yoshimura, Akihiko .

NATURE COMMUNICATIONS, 2011, 2

[9] Vitexin and isovitexin from the Leaves of Ficus deltoidea with in-vivo α-glucosidase inhibition [J].

Choo, C. Y. ;

Sulong, N. Y. ;

Man, F. ;

Wong, T. W. .

JOURNAL OF ETHNOPHARMACOLOGY, 2012, 142 (03) :776-781

[10] Olive leaf extract decreases age-induced oxidative stress in major organs of aged rats [J].

Coban, Jale ;

Oztezcan, Serdar ;

Dogru-Abbasoglu, Semra ;

Bingul, Ilknur ;

Yesil-Mizrak, Kubra ;

Uysal, Mujdat .

GERIATRICS & GERONTOLOGY INTERNATIONAL, 2014, 14 (04) :996-1002

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