Tandem manganese(III)-based oxidative free-radical cyclizations terminated by addition to furans. Formal synthesis of 15-acetoxypallescensin-A

被引：13

作者：

Snider, BB ^{[1
]}

O'Hare, SM ^{[1
]}

机构：

[1] Brandeis Univ, Dept Chem, Waltham, MA 02454 USA

来源：

SYNTHETIC COMMUNICATIONS | 2001年 / 31卷 / 24期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1081/SCC-100108225

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Reaction of beta -keto ester 12 with 2 equiv. of Mn(OAc)(3). 2H(2)O in KOAc-buffered MeOH followed by acidic workup afforded 51 % of tricyclic furan 14 indicating that oxidative cyclizations can be terminated by addition to furans. Reduction of 14 with LAH provided 7, completing a five-step formal synthesis of 15-acetoxypallescensin-A.

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收藏

页码：3753 / 3758

页数：6

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