High throughput synthesis of peptide α-thioesters through the use of "volatilizable" support

被引：12

作者：

Li, Yangmei ^{[1
,2
]}

Yu, Yongping ^{[1
]}

Giulianotti, Marc ^{[2
]}

Houghten, Richard A. ^{[1
,2
]}

机构：

[1] Zhejiang Univ, Coll Pharmaceut Sci, Hangzhou 310058, Zhejiang, Peoples R China

[2] Torrey Pines Inst Mol Studies, San Diego, CA 92121 USA

来源：

JOURNAL OF COMBINATORIAL CHEMISTRY | 2008年 / 10卷 / 05期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1021/cc800076b

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

[No abstract available]

引用

页码：613 / 616

页数：4

共 18 条

[1] Backbone amide linker (BAL) strategy for Nα-9-fluorenylmethoxycarbonyl (Fmoc) solid-phase synthesis of unprotected peptide p-nitroanilides and thioesters [J].

Alsina, J ;

Yokum, TS ;

Albericio, F ;

Barany, G .

JOURNAL OF ORGANIC CHEMISTRY, 1999, 64 (24) :8761-8769

[2] Fmoc solid-phase synthesis of peptide thioesters by masking as trithioortho esters [J].

Brask, J ;

Albericio, F ;

Jensen, KJ .

ORGANIC LETTERS, 2003, 5 (16) :2951-2953

[3] 3-thiopropionic acid as a highly versatile multidetachable thioester resin linker [J].

Camarero, JA ;

Adeva, A ;

Muir, TW .

LETTERS IN PEPTIDE SCIENCE, 2000, 7 (01) :17-21

[4] Extending the applicability of native chemical ligation [J].

Canne, LE ;

Bark, SJ ;

Kent, SBH .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1996, 118 (25) :5891-5896

[5] Native chemical ligation at phenylalanine [J].

Crich, David ;

Banerjee, Abhisek .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2007, 129 (33) :10064-+

[6] Synthesis of native proteins by chemical ligation [J].

Dawson, PE ;

Kent, SBH .

ANNUAL REVIEW OF BIOCHEMISTRY, 2000, 69 :923-960

[7] Protein synthesis by native chemical ligation: Expanded scope by using straightforward methodology [J].

Hackeng, TM ;

Griffin, JH ;

Dawson, PE .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (18) :10068-10073

[8] Volatilizable supports for high-throughput organic synthesis [J].

Houghten, RA ;

Yu, YP .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2005, 127 (24) :8582-8583

[9] GENERAL-METHOD FOR THE RAPID SOLID-PHASE SYNTHESIS OF LARGE NUMBERS OF PEPTIDES - SPECIFICITY OF ANTIGEN-ANTIBODY INTERACTION AT THE LEVEL OF INDIVIDUAL AMINO-ACIDS [J].

HOUGHTEN, RA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (15) :5131-5135

[10] Solid phase synthesis of peptide C-terminal thioesters by Fmoc/t-Bu chemistry [J].

Ingenito, R ;

Bianchi, E ;

Fattori, D ;

Pessi, A .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1999, 121 (49) :11369-11374

← 1 2 →