Organocatalytic Enantioselective Continuous-Flow Cyclopropanation

被引：50

作者：

Llanes, Patricia ^{[1
]}

Rodriguez-Escrich, Carles ^{[1
]}

Sayalero, Sonia ^{[1
]}

Pericas, Miquel A. ^{[1
,2
]}

机构：

[1] Barcelona Inst Sci & Technol, Inst Chem Res Catalonia ICIQ, Ave Paisos Catalans,16, Tarragona 43007, Spain

[2] Univ Barcelona, Dept Quim Inorgan & Organ, E-08028 Barcelona, Spain

来源：

ORGANIC LETTERS | 2016年 / 18卷 / 24期

关键词：

SUPPORTED CHIRAL ORGANOCATALYSTS; DIPHENYLPROLINOL SILYL ETHERS; ASYMMETRIC MICHAEL ADDITION; ALPHA-AMINO-ACIDS; ALPHA; BETA-UNSATURATED ALDEHYDES; EFFICIENT ORGANOCATALYSTS; ALKYLATION REACTIONS; NATURAL OCCURRENCE; ORGANIC-SYNTHESIS; CATALYST;

D O I：

10.1021/acs.orglett.6b03156

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A set of six solid-supported diarylprolinol catalysts (varying on the anchoring strategy and the type of polymeric support) has been prepared and applied to the enantioselective cyclopropanation reaction. The selected candidate allows implementation of a long flow experiment (48 h) and generates a library of 12 cyclopropanes by sequential flow experiments. The mildness and utility of the method have enabled a telescoped process in which the outstream is directly used in a Wittig flow reaction.

引用

页码：6292 / 6295

页数：4

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2-E

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