Association between environmental exposure to benzene and oxidative damage to nucleic acids in children

被引:0
|
作者
Andreoli, Roberta [1 ,2 ]
Protano, Roberta [3 ]
Manini, Paola [1 ]
De Palma, G. [4 ]
Goldoni, M. [1 ,2 ]
Petyx, Marta [5 ]
Rondinone, Bruna Maria [5 ]
Vitali, M. [3 ]
Mutti, A. [1 ]
机构
[1] Univ Parma, Dept Clin Med Nephrol & Hlth Sci, Lab Ind Toxicol, I-43126 Parma, Italy
[2] CERT Univ Parma, INAIL Res Area, Parma, Italy
[3] Univ Roma La Sapienza, Dept Publ Hlth & Infect Dis, Rome, Italy
[4] Univ Brescia, Dept Expt & Appl Med, Sect Occupat Hlth & Ind Hyg, Brescia, Italy
[5] Dept Occupat Med, INAIL Res Area, Rome, Italy
来源
MEDICINA DEL LAVORO | 2012年 / 103卷 / 05期
关键词
Benzene exposure; S-phenylmercapturic acid; nucleic acid oxidation; DNA-DAMAGE; OCCUPATIONAL-EXPOSURE; GENETIC POLYMORPHISMS; ORGANIC-SOLVENTS; URBAN AIR; BIOMARKERS; NICOTINE; SMOKING; MARKER; HEALTH;
D O I
暂无
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Objectives: To evaluate the association between environmental exposure to benzene and oxidative damage to nucleic acids in children, also considering the role of Environmental Tobacco Smoke (ETS). Methods: 396 children living in central Italy were recruited in districts with different urbanization and air pollution. All biomarkers were determined in spot urine samples by mass spectrometric techniques to assess exposure [benzene (U-Benz), and its metabolites (t,t-muconic and S-phenylmercapturic acids, t,t-MA and S-PMA, respectively), cotinine] and nucleic acid oxidation [8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodGuo), 8-oxo-7,8-dihydroguanosine (8-oxoGuo), and 8-oxo-7,8-dihydroguanine (8-oxoGua)]. Results: Biomarkers of exposure and nucleic acid oxidation increased with urbanization and were correlated with each other (r>0.18, p<0.005). In a multiple linear regression model, benzene exposure, assessed by S-PMA and t, t-MA, was associated (p<0.0001) with both 8-oxodGuo (R-2=0.392) and 8-oxoGuo (R-2=0.193) in all areas of residence, with similar slopes. Conclusions: (i) Biomarkers of exposure to benzene increased as a function of environmental air pollution and urbanization level; (ii) U-Benz clearly distinguished both exposure to ETS and areas of residence, whereas benzene metabolites were associated only with the latter; (iii) the variance of 8-oxodGuo and 8-oxoGuo was accounted for by environmental benzene exposure, thus suggesting that benzene is a good tracer of other components of complex mixtures of pollutants causing oxidative damage to nucleic acids.
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收藏
页码:324 / 337
页数:14
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