Synthesis and Type I/Type II photosensitizing properties of a novel amphiphilic zinc phthalocyanine

被引：52
作者：
Wei, SH
Zhou, JH
Huang, DY [1 ]
Wang, XS
Zhang, BW
Shen, J
机构：
[1] Shanghai Jiao Tong Univ, Sch Chem & Chem Technol, Shanghai 200240, Peoples R China
[2] Nanjing Normal Univ, Jiangsu Engn Res Ctr Biomed Funct Mat, Nanjing 210097, Peoples R China
[3] Chinese Acad Sci, Tech Inst Phys & Chem, Beijing 100101, Peoples R China
来源：
DYES AND PIGMENTS | 2006年 / 71卷 / 01期
关键词：
sulfonated zinc phthalocyanine; active oxygen; amphiphilicity; ESR; PDT;
D O I：
10.1016/j.dyepig.2005.06.016
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
A novel amphiphilic zinc phthalocyanine (ZnPcLTs) has been synthesized, which possesses good amphiphilicity, and low aggregation. The generation efficiency of singlet oxygen and other active oxygen species' trapping rate studies were studied by electron spin resonance (ESR) spectroscopy. The results indicated that the photosensitizer possessed a higher active oxygen species generation efficiency than that of hematoporphyrin. The results of photodamage experiments towards calf-thymus DNA indicated that ZnPcLTs is a promising photosensitizer candidate for photodynamic therapy. (c) 2005 Elsevier Ltd. All rights reserved.
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收藏
页码：61 / 67
页数：7
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