Predicting the effects of chemoradiotherapy for squamous cell carcinoma of the esophagus by induction chemotherapy response assessed by positron emission tomography: toward PET-response-guided selection of chemoradiotherapy or esophagectomy

被引：14

作者：

Ishihara, Ryu ^{[1
]}

Yamamoto, Sachiko ^{[1
]}

Iishi, Hiroyasu ^{[1
]}

Nagai, Kengo ^{[1
]}

Matui, Fumi ^{[1
]}

Kawada, Natsuko ^{[1
]}

Ohta, Takashi ^{[1
]}

Kanzaki, Hiromitsu ^{[1
]}

Hanafusa, Masao ^{[1
]}

Hanaoka, Noboru ^{[1
]}

Takeuchi, Yoji ^{[1
]}

Higashino, Koji ^{[1
]}

Uedo, Noriya ^{[1
]}

Sugimoto, Naotoshi ^{[2
]}

Kawaguchi, Yoshifumi ^{[3
]}

Nishiyama, Kinji ^{[3
]}

Motoori, Masaaki ^{[4
]}

Yano, Masahiko ^{[4
]}

Hosoki, Takuya ^{[5
]}

机构：

[1] Osaka Med Ctr Canc & Cardiovasc Dis, Dept Gastrointestinal Oncol, Higashinari Ku, Osaka 5378511, Japan

[2] Osaka Med Ctr Canc & Cardiovasc Dis, Dept Clin Oncol, Osaka 5378511, Japan

[3] Osaka Med Ctr Canc & Cardiovasc Dis, Dept Radiat Oncol, Osaka 5378511, Japan

[4] Osaka Med Ctr Canc & Cardiovasc Dis, Dept Surg, Osaka 5378511, Japan

[5] Morinomiya Clin, Osaka, Japan

来源：

INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY | 2012年 / 17卷 / 03期

关键词：

Esophageal cancer; Squamous-cell type; Chemoradiotherapy; Complete response; Positron emission tomography; TUMOR METABOLIC-ACTIVITY; ESOPHAGOGASTRIC JUNCTION; DEFINITIVE CHEMORADIOTHERAPY; PREOPERATIVE CHEMOTHERAPY; SURGICAL RESECTION; CANCER; THERAPY; EXPRESSION; SURGERY; TRIAL;

D O I：

10.1007/s10147-011-0278-3

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We have developed a treatment protocol for esophageal cancer involving a single course of induction chemotherapy followed by chemoradiotherapy. This study aimed to determine if it was possible to predict the effects of chemoradiotherapy on the basis of the response to induction chemotherapy, assessed by positron emission tomography (PET). Sixteen patients with Stage II-IVA esophageal cancer were treated using this protocol from April 2007 to July 2010. Chemotherapy involved a fluorouracil and platinum-based combination regimen. All patients received PET scans before and 12-24 days after the beginning of induction chemotherapy. Associations between the response to induction chemotherapy assessed by PET and the effects of chemoradiotherapy were evaluated. Induction chemotherapy followed by chemoradiotherapy resulted in complete response (CR) in 10 of the 16 patients. The reduction in maximum standardized uptake value (SUVmax) was 58 +/- A 12% in patients with CR (n = 10), compared with 14 +/- A 16% in patients without CR (n = 6) (P < 0.0001). Using a cut-off value of 55% for SUVmax reduction rate, eight of 10 cancers with CR and six of six cancers without CR were correctly identified, providing a sensitivity and specificity of 80 and 100%, respectively. The overall 1-year survival rates for patients with an SUVmax reduction rate > 55% (responders) were 100%, compared with 60% for patients with an SUVmax reduction rate a parts per thousand currency sign55% (non-responders), respectively. The response to a single course of induction therapy assessed by PET was significantly associated with the effects of chemoradiotherapy.

引用

页码：225 / 232

页数：8

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