A novel role of suppressor of cytokine signaling-2 in the regulation of TrkA neurotrophin receptor biology

被引：11
作者：
Uren, Rachel T. [1 ]
Turbic, Alisa [1 ]
Wong, Agnes W. [1 ]
Klein, Reuben [1 ]
Murray, Simon S. [1 ]
Turnley, Ann M. [1 ]
机构：
[1] Univ Melbourne, Dept Anat & Neurosci, Ctr Neurosci Res, Parkville, Vic 3010, Australia
来源：
JOURNAL OF NEUROCHEMISTRY | 2014年 / 129卷 / 04期
基金：
澳大利亚国家健康与医学研究理事会; 英国医学研究理事会;
关键词：
MAPKs; neurite outgrowth; neurotrophin; signal transduction; survival; ubiquitin; NERVE GROWTH-FACTOR; NEURITE OUTGROWTH; SENSORY NEURONS; TYROSINE KINASE; DIFFERENTIAL EXPRESSION; RETROGRADE TRANSPORT; ACTIVATED TRKA; PROTEIN; TRAFFICKING; INHIBITION;
D O I：
10.1111/jnc.12671
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Neurotrophins such as Nerve growth factor (NGF) are important for the neurite outgrowth and survival of sensory neurons. Increased expression of SOCS2 enhanced NGF-dependent neurite outgrowth and increased TrkA receptor surface localization in dorsal root ganglion neurons and PC12 cells. This correlated with increased and prolonged activation of pAKT and pErk1/2. In 293T cells SOCS2 was shown to interact with the TrkA receptor in the juxtamembrane region. We thus propose that SOCS2 is a novel regulator of neurotrophin signaling.
引用
收藏
页码：614 / 627
页数：14
相关论文
共 82 条
  • [21] Association of the atypical protein kinase C-interacting protein p62/ZIP with nerve growth factor receptor TrkA regulates receptor trafficking and Erk5 signaling
    Geetha, T
    Wooten, MW
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (07) : 4730 - 4739
  • [22] Ubiquitination of TrkA by Nedd4-2 regulates receptor lysosomal targeting and mediates receptor signaling
    Georgieva, Maya V.
    de Pablo, Yolanda
    Sanchis, Daniel
    Comella, Joan X.
    Llovera, Marta
    [J]. JOURNAL OF NEUROCHEMISTRY, 2011, 117 (03) : 479 - 493
  • [23] Loss of Braking Signals During Inflammation A Factor Affecting the Development and Disease Course of Multiple Sclerosis
    Gilli, Francesca
    Navone, Nicole Desiree
    Perga, Simona
    Marnetto, Fabiana
    Caldano, Marzia
    Capobianco, Marco
    Pulizzi, Annalisa
    Malucchi, Simona
    Bertolotto, Antonio
    [J]. ARCHIVES OF NEUROLOGY, 2011, 68 (07) : 879 - 888
  • [24] Learning from Nature: Pregnancy Changes the Expression of Inflammation-Related Genes in Patients with Multiple Sclerosis
    Gilli, Francesca
    Lindberg, Raija L. P.
    Valentino, Paola
    Marnetto, Fabiana
    Malucchi, Simona
    Sala, Arianna
    Capobianco, Marco
    di Sapio, Alessia
    Sperli, Francesca
    Kappos, Ludwig
    Calogero, Raffaele A.
    Bertolotto, Antonio
    [J]. PLOS ONE, 2010, 5 (01):
  • [25] Differential expression and potential role of SOCS1 and SOCS3 in Wallerian degeneration in injured peripheral nerve
    Girolami, Elizabeth I.
    Bouhy, Delphine
    Haber, Michael
    Johnson, Howard
    David, Samuel
    [J]. EXPERIMENTAL NEUROLOGY, 2010, 223 (01) : 173 - 182
  • [26] SOCS2 induces neurite outgrowth by regulation of epidermal growth factor receptor activation
    Goldshmit, Y
    Walters, CE
    Scott, HJ
    Greenhalgh, CJ
    Turnley, AM
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (16) : 16349 - 16355
  • [27] Suppressor of cytokine signalling-2 and epidermal growth factor regulate neurite outgrowth of cortical neurons
    Goldshmit, Y
    Greenhalgh, CJ
    Turnley, AM
    [J]. EUROPEAN JOURNAL OF NEUROSCIENCE, 2004, 20 (09) : 2260 - 2266
  • [28] Biological evidence that SOCS-2 can act either as an enhancer or suppressor of growth hormone signaling
    Greenhalgh, CJ
    Metcalf, D
    Thaus, AL
    Corbin, JE
    Uren, R
    Morgan, PO
    Fabri, LJ
    Zhang, JG
    Martin, HM
    Willson, TA
    Billestrup, N
    Nicola, NA
    Baca, M
    Alexander, WS
    Hilton, DJ
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (43) : 40181 - 40184
  • [29] SOCS2 negatively regulates growth hormone action in vitro and in vivo
    Greenhalgh, CJ
    Rico-Bautista, E
    Lorentzon, M
    Thaus, AL
    Morgan, PO
    Willson, TA
    Zervoudakis, P
    Metcalf, D
    Street, I
    Nicola, NA
    Nash, AD
    Fabri, LJ
    Norstedt, G
    Ohlsson, C
    Flores-Morales, A
    Alexander, WS
    Hilton, DJ
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 2005, 115 (02) : 397 - 406
  • [30] Grimes ML, 1996, J NEUROSCI, V16, P7950
123456789