A novel role of suppressor of cytokine signaling-2 in the regulation of TrkA neurotrophin receptor biology

被引：11

作者：

Uren, Rachel T. ^{[1
]}

Turbic, Alisa ^{[1
]}

Wong, Agnes W. ^{[1
]}

Klein, Reuben ^{[1
]}

Murray, Simon S. ^{[1
]}

Turnley, Ann M. ^{[1
]}

机构：

[1] Univ Melbourne, Dept Anat & Neurosci, Ctr Neurosci Res, Parkville, Vic 3010, Australia

来源：

JOURNAL OF NEUROCHEMISTRY | 2014年 / 129卷 / 04期

基金：

英国医学研究理事会; 澳大利亚国家健康与医学研究理事会;

关键词：

MAPKs; neurite outgrowth; neurotrophin; signal transduction; survival; ubiquitin; NERVE GROWTH-FACTOR; NEURITE OUTGROWTH; SENSORY NEURONS; TYROSINE KINASE; DIFFERENTIAL EXPRESSION; RETROGRADE TRANSPORT; ACTIVATED TRKA; PROTEIN; TRAFFICKING; INHIBITION;

D O I：

10.1111/jnc.12671

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Neurotrophins such as Nerve growth factor (NGF) are important for the neurite outgrowth and survival of sensory neurons. Increased expression of SOCS2 enhanced NGF-dependent neurite outgrowth and increased TrkA receptor surface localization in dorsal root ganglion neurons and PC12 cells. This correlated with increased and prolonged activation of pAKT and pErk1/2. In 293T cells SOCS2 was shown to interact with the TrkA receptor in the juxtamembrane region. We thus propose that SOCS2 is a novel regulator of neurotrophin signaling.

引用

页码：614 / 627

页数：14

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