A novel role of suppressor of cytokine signaling-2 in the regulation of TrkA neurotrophin receptor biology

被引：11
作者：
Uren, Rachel T. [1 ]
Turbic, Alisa [1 ]
Wong, Agnes W. [1 ]
Klein, Reuben [1 ]
Murray, Simon S. [1 ]
Turnley, Ann M. [1 ]
机构：
[1] Univ Melbourne, Dept Anat & Neurosci, Ctr Neurosci Res, Parkville, Vic 3010, Australia
来源：
JOURNAL OF NEUROCHEMISTRY | 2014年 / 129卷 / 04期
基金：
澳大利亚国家健康与医学研究理事会; 英国医学研究理事会;
关键词：
MAPKs; neurite outgrowth; neurotrophin; signal transduction; survival; ubiquitin; NERVE GROWTH-FACTOR; NEURITE OUTGROWTH; SENSORY NEURONS; TYROSINE KINASE; DIFFERENTIAL EXPRESSION; RETROGRADE TRANSPORT; ACTIVATED TRKA; PROTEIN; TRAFFICKING; INHIBITION;
D O I：
10.1111/jnc.12671
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Neurotrophins such as Nerve growth factor (NGF) are important for the neurite outgrowth and survival of sensory neurons. Increased expression of SOCS2 enhanced NGF-dependent neurite outgrowth and increased TrkA receptor surface localization in dorsal root ganglion neurons and PC12 cells. This correlated with increased and prolonged activation of pAKT and pErk1/2. In 293T cells SOCS2 was shown to interact with the TrkA receptor in the juxtamembrane region. We thus propose that SOCS2 is a novel regulator of neurotrophin signaling.
引用
收藏
页码：614 / 627
页数：14
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