Systematic genetic analysis of transcription factors to map the fission yeast transcription-regulatory network

被引：6

作者：

Chua, Gordon ^{[1
,2
]}

机构：

[1] Univ Calgary, Inst Biocomplex & Informat, Calgary, AB T2N 1N4, Canada

[2] Univ Calgary, Dept Biol Sci, Calgary, AB T2N 1N4, Canada

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2013年 / 41卷

基金：

加拿大健康研究院; 加拿大创新基金会;

关键词：

fission yeast; functional genomics; Schizosaccharomyces pombe; transcriptional-regulatory network; transcription factor; FUNCTIONAL-CHARACTERIZATION; SEXUAL-DIFFERENTIATION; EXPRESSION; IDENTIFICATION; MEIOSIS; GENOME; ACTIVATION; PHEROMONE; PROGRAM; TARGETS;

D O I：

10.1042/BST20130224

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mapping transcriptional-regulatory networks requires the identification of target genes, binding specificities and signalling pathways of transcription factors. However, the characterization of each transcription factor sufficiently for deciphering such networks remains laborious. The recent availability of overexpression and deletion strains for almost all of the transcription factor genes in the fission yeast Schizosaccharomyces pombe provides a valuable resource to better investigate transcription factors using systematic genetics. In the present paper, I review and discuss the utility of these strain collections combined with transcriptome profiling and genome-wide chromatin immunoprecipitation to identify the target genes of transcription factors.

引用

页码：1696 / 1700

页数：5

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