Long non-coding RNA MAGI2-AS3 inhibits breast cancer cell migration and invasion via sponging microRNA-374a

被引：50
作者：
Du, Shanmei [1 ]
Hu, Wei [2 ,3 ]
Zhao, Yi [4 ]
Zhou, Hengzhong [1 ]
Wen, Wei [1 ]
Xu, Miao [5 ]
Zhao, Peiqing [6 ]
Liu, Kui [3 ,6 ]
机构：
[1] Zibo Vocat Inst, Zibo 255314, Shandong, Peoples R China
[2] Zibo Cent Hosp, Dept Breast & Thyroid Surg, Zibo 255036, Shandong, Peoples R China
[3] Zibo Cent Hosp, Zibo City Key Lab Individualized Diag & Transform, 54 Gongqingtuan Rd, Zibo 255036, Shandong, Peoples R China
[4] Shandong Univ, Sch Stomatol, Jinan 250012, Shandong, Peoples R China
[5] Seventh Peoples Hosp Zibo, Zibo 255040, Shandong, Peoples R China
[6] Zibo Cent Hosp, Ctr Translat Med, Zibo 255036, Shandong, Peoples R China
来源：
CANCER BIOMARKERS | 2019年 / 24卷 / 03期
基金：
中国国家自然科学基金;
关键词：
lncRNA MAGI2-AS3; breast cancer; migration; invasion; miR-374a; PTEN; EXPRESSION; TUMORIGENESIS; HALLMARKS; MIR-374A; INSIGHTS; MARKER;
D O I：
10.3233/CBM-182216
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Long non-coding RNAs (lncRNAs) are non-protein-coding transcripts that play important roles in tumorigenesis and tumor progression. Our study aimed to explore the role of lncRNA MAGI2-AS3 in breast cancer metastatic progression. In the present study, our results showed that MAGI2-AS3 can inhibit the migration and invasion of breast cancer cells. In addition, an increase in MAGI2-AS3 can inhibit microRNA-374a (miR-374a) expression in breast cancer cells. Bioinformatic analysis predicted the correlation between MAGI2-AS3 and miR-374a. Phosphatase and tensin homolog (PTEN) was found to be an novel mRNA target of miR-374a. MAGI2-AS3 upregulation inhibited breast cancer metastatic progression by decreasing miR-374a and enhancing PTEN expression. Together, our data revealed that lncRNA MAGI2-AS3 is involved in breast cancer cell progression by regulating the miR-374a-PTEN axis. These findings offer new insight into treatment strategies for breast cancer.
引用
收藏
页码：269 / 277
页数：9
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