Hybrid Gastric Cancer Exosome as Potential Drug Carrier for Targeted Gastric Cancer Therapy

被引：2

作者：

Tian, Qing ^{[1
]}

Guo, Ying ^{[2
]}

Li, Dan ^{[3
]}

Dong, Liang ^{[4
]}

机构：

[1] Hebei Med Univ, Hosp 1, Dept Thorac Surg, Shijiazhuang 050031, Hebei, Peoples R China

[2] Hebei Med Univ, Hosp 1, Dept Oncol, Shijiazhuang 050031, Hebei, Peoples R China

[3] Jingxing Cty Hosp, Dept Thorac Surg, Shijiazhuang 050030, Hebei, Peoples R China

[4] Hebei Med Univ, Hosp 1, Dept Med, Shijiazhuang 050031, Hebei, Peoples R China

来源：

JOURNAL OF BIOMATERIALS AND TISSUE ENGINEERING | 2022年 / 12卷 / 11期

关键词：

Liposome; Exosome; Gastric Cancer; Drug Carrier; LIPID NANOPARTICLES; NANOMEDICINE; SIZE;

D O I：

10.1166/jbt.2022.3167

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Gastric cancer is among the leading lethal cancer types in the world. However, its five year survival rate is far from satisfactory. Therefore, the development of targeted cancer gastric cancer therapy is a promising way to cure gastric cancer. Gastric cancer exosome is reported to have high caner targeting efficacy, but its yield is relatively low. Herein, we proposed a facile way to construct hybrid gastric cancer exosome (HGCE) with high yield as potential drug carrier for targeted gastric cancer therapy. The doxorubicin (Dox) loaded HGCE (Dox/HGCE) was developed as drug delivery system (DDS) to treat gastric cancer. In vitro and in vivo results demonstrated that Dox/HGCE showed not only high and specific homing ability to the gastric cancer cells (SGC7901) but also good anticancer performance which can be a promising DDS for gastric cancer therapy.

引用

页码：2228 / 2232

页数：5

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