Uniportal versus multiportal video-assisted thoracoscopic anatomical resection for NSCLC: a meta-analysis

Background Uniportal video-assisted thoracoscopic surgery (U-VATS) has recently emerged as an alternative procedure for non-small cell lung cancer (NSCLC); however, whether U-VATS has advantages over multiportal VATS (M-VATS) remains unknown. Methods We performed a systematic review of two databases (Pubmed and Web of Science) to search comparative studies of U-VATS and M-VATS anatomical pulmonary resection for NSCLC. Operative time, blood loss, number of resected lymph nodes, drainage duration, length of postoperative stay, pain in postoperative day 1(POD1) and conversion rates were retrieved to estimate the comparison of outcomes. A subgroup analysis stratified by study type (propensity-matched analysis and randomized-controlled trial versus non-propensity matched analysis) was performed. Result A total of 20 studies with 4142 patients were included in this meta-analysis. U-VATS was performed on 1869 patients, whereas the other 2173 patients underwent M-VATS. This meta-analysis showed that there was no significant difference in operative time (U-VATS: 146.48 +/- 55.07 min versus M-VATS: 171.70 +/- 79.40 min,P = 0.81), blood loss (74.49 +/- 109.03 mL versus 95.48 +/- 133.67 mL,P = 0.18), resected lymph nodes (17.28 +/- 9.46 versus 18.31 +/- 10.17,P = 0.62), conversion rate (6.18% versus 4.34%,P = 0.14), drainage duration (3.90 +/- 2.94 days versus 4.44 +/- 3.12 days,p = 0.09), length of postoperative stay (6.16 +/- 4.40 days versus 6.45 +/- 4.80 days,P = 0.22), and pain in POD1 (3.94 +/- 1.68 versus 3.59 +/- 2.76,p = 0.07). Subgroup analysis showed the value of PSM and RCT group consistency with overall value. Conclusion This up-to-date meta-analysis shows that the perioperative outcomes of U-VATS and M-VATS anatomical pulmonary resection are equivalent. In addition, the differences in long-term outcomes of these two approaches are still unclear. Thoracic surgeons should pay more emphasize on providing high-quality and personalized surgical care for patients, to improve the survival ultimately.