The Impact of Antipsychotic Treatment on Neurological Soft Signs in Patients with Predominantly Negative Symptoms of Schizophrenia

被引:4
作者
Petrescu, Cristian [1 ,2 ]
Papacocea, Ioana R. R.
Vilciu, Crisanda [3 ,4 ]
Mihalache, Oana A. A. [1 ,4 ]
Vlad, Diana M. M.
Marian, Gabriela [5 ,6 ]
Focseneanu, Brindusa E. E. [2 ,6 ]
Sima, Cristian T. T.
Ciobanu, Constantin A. A. [7 ]
Riga, Sorin [8 ,9 ]
Ciobanu, Adela M. M. [1 ,2 ]
机构
[1] Carol Davila Univ Med & Pharm, Fac Med, Neurosci Dept, Discipline Psychiat, Bucharest 020021, Romania
[2] Prof Dr Alexandru Obregia Clin Hosp Psychiat, Dept Psychiat, Bucharest 041914, Romania
[3] Carol Davila Univ Med & Pharm, Dept Neurol, Bucharest 020021, Romania
[4] Neurol Clin Fundeni Clin Inst, Bucharest 022328, Romania
[5] Acad Romanian Scientists, Bucharest 927180, Romania
[6] Titu Maiorescu Univ Med, Dept Psychiat & Psychol, Bucharest 040051, Romania
[7] Titu Maiorescu Univ Med, Fac Med, Bucharest 040051, Romania
[8] Prof Dr Alexandru Obregia Clin Hosp Psychiat, Dept Stress Res & Prophylaxis, Bucharest 041914, Romania
[9] Romanian Acad Med Sci, Bucharest 927180, Romania
关键词
antipsychotics; schizophrenia; neurological abnormalities; neurological soft signs; NEUROLEPTIC-NAIVE; RATING-SCALE; DOUBLE-BLIND; DISORDER; ABNORMALITIES; PREDICTORS; EQUIVALENTS; RISPERIDONE; DYSFUNCTION; TOMOGRAPHY;
D O I
10.3390/biomedicines10112939
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Schizophrenia is a complex and incompletely elucidated pathology that affects sensorimotor function and also produces numerous therapeutic challenges. The aims of this cross-sectional study were to identify the profile of neurological soft signs (NSS) in patients with predominantly negative symptoms of schizophrenia (PNS) compared with patients with schizophrenia who do not present a predominance of negative symptoms (NPNS) and also to objectify the impact of treatment on the neurological function of these patients. Ninety-nine (n = 99; 56 females and 43 males) patients diagnosed with schizophrenia according to DSM-V were included; these patients were undergoing antipsychotic (4 typical antipsychotics, 86 atypical antipsychotics, and 9 combinations of two atypical antipsychotics) or anticholinergic treatment (24 out of 99) at the time of evaluation, and the PANSS was used to identify the patients with predominantly negative symptoms (n = 39), the Neurological Evaluation Scale (NES) was used for the evaluation of neurological soft signs (NSS), and the SAS was used for the objectification of the extrapyramidal side effects induced by the neuroleptic treatment, which was converted to chlorpromazine equivalents (CPZE). The study's main finding was that, although the daily dose of CPZE did not represent a statistically significant variable, in terms of neurological soft signs, patients with PNS had higher rates of NSS.
引用
收藏
页数:22
相关论文
共 98 条
[31]  
Flashman LA, 1996, AM J PSYCHIAT, V153, P526
[32]   Paternal age and specific neurological soft signs as reliable and valid neurobiological markers for the diagnosis of patients with schizophrenia [J].
Fountoulakis, Konstantinos N. ;
Panagiotidis, Panagiotis ;
Tegos, Thomas ;
Kimiskidis, Vasileios ;
Nimatoudis, Ioannis .
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE, 2022, 272 (06) :1087-1096
[33]   Neurological soft signs significantly differentiate schizophrenia patients from healthy controls [J].
Fountoulakis, Konstantinos N. ;
Panagiotidis, Panagiotis ;
Gonda, Xenia ;
Kimiskidis, Vasilios ;
Nimatoudis, Ioannis .
ACTA NEUROPSYCHIATRICA, 2018, 30 (02) :97-105
[34]   EPA guidance on assessment of negative symptoms in schizophrenia [J].
Galderisi, S. ;
Mucci, A. ;
Dollfus, S. ;
Nordentoft, M. ;
Falkai, P. ;
Kaiser, S. ;
Giordano, G. M. ;
Vandevelde, A. ;
Nielsen, M. O. ;
Glenthoj, L. B. ;
Sabe, M. ;
Pezzella, P. ;
Bitter, I. ;
Gaebel, W. .
EUROPEAN PSYCHIATRY, 2021, 64 (01)
[35]   Historical, psychopathological, neurological, and neuropsychological aspects of deficit schizophrenia: A multicenter study [J].
Galderisi, S ;
Maj, M ;
Mucci, A ;
Cassano, GB ;
Invernizzi, G ;
Rossi, A ;
Vita, A ;
Dell'Osso, L ;
Daneluzzo, E ;
Pini, S .
AMERICAN JOURNAL OF PSYCHIATRY, 2002, 159 (06) :983-990
[36]   Updated perspectives on the clinical significance of negative symptoms in patients with schizophrenia [J].
Giordano, Giulia Maria ;
Caporusso, Edoardo ;
Pezzella, Pasquale ;
Galderisi, Silvana .
EXPERT REVIEW OF NEUROTHERAPEUTICS, 2022, 22 (07) :541-555
[37]   Functional connectivity of the ventral tegmental area and avolition in subjects with schizophrenia: a resting state functional MRI study [J].
Giordano, Giulia Maria ;
Stanziano, Mario ;
Papa, Michele ;
Mucci, Armida ;
Prinster, Anna ;
Soricelli, Andrea ;
Galderisi, Silvana .
EUROPEAN NEUROPSYCHOPHARMACOLOGY, 2018, 28 (05) :589-602
[38]   PREMORBID ADJUSTMENT AS A PREDICTOR OF PHENOMENOLOGICAL AND NEUROBIOLOGICAL INDEXES IN SCHIZOPHRENIA [J].
GUPTA, S ;
RAJAPRABHAKARAN, R ;
ARNDT, S ;
FLAUM, M ;
ANDREASEN, NC .
SCHIZOPHRENIA RESEARCH, 1995, 16 (03) :189-197
[39]  
GUPTA S, 1995, AM J PSYCHIAT, V152, P191
[40]  
Guy W, 1976, NIH PSYCHOPHARMACOLO, P76