Induction of c-Fos immunoreactivity in the amygdala of mice expressing anxiety-like behavior after local perfusion of veratrine in the prelimbic medial prefrontal cortex

被引：8
|
作者：
Yamada, Misa [1 ]
Saitoh, Akiyoshi [1 ]
Ohashi, Masanori [1 ,2 ]
Suzuki, Satoshi [1 ,2 ]
Oka, Jun-Ichiro [2 ]
Yamada, Mitsuhiko [1 ]
机构：
[1] Natl Ctr Neurol & Psychiat, Natl Inst Mental Hlth, Dept Neuropsychopharmacol, Kodaira, Tokyo 1878553, Japan
[2] Tokyo Univ Sci, Fac Pharmaceut Sci, Pharmacol Lab, Chiba 2788510, Japan
来源：
JOURNAL OF NEURAL TRANSMISSION | 2015年 / 122卷 / 08期
关键词：
Immunohistochemistry; Innate anxiety; Glutamate; Microdialysis; Open-field test; BASOLATERAL AMYGDALA; EXCITOTOXIC LESIONS; CONDITIONED FEAR; EXTINCTION; NUCLEUS; INNATE; MEMORY; RATS;
D O I：
10.1007/s00702-015-1373-9
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Local perfusion of the sodium channel activator veratrine in mouse prelimbic medial prefrontal cortex (PL) induced c-Fos immunoreactivity in the sub-regions of amygdala. Co-perfusion of the NMDA receptor antagonist MK-801 diminished the c-Fos expression. Significant correlations were observed between c-Fos immunoreactivity and behavioral measures in the open-field test. The PL stimulation activates a neural network projecting to the amygdala via NMDA receptor-mediated glutamatergic neurotransmission. Anxiety-like behavior induced after the PL stimulation may be partly mediated through the activation of amygdala.
引用
收藏
页码：1203 / 1207
页数：5
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