Cytotoxic lignans from the stems of Helicteres hirsuta collected in Indonesia

被引：43

作者：

Chin, YW

Jones, WP

Rachman, I

Riswan, S

Kardono, LBS

Chai, HB

Farnsworth, NR

Cordell, GA

Swanson, SM

Cassady, JM

Kinghorn, AD ^{[1
]}

机构：

[1] Ohio State Univ, Coll Pharm, Div Med Chem & Pharmacognosy, Columbus, OH 43210 USA

[2] Indonesian Inst Sci, Biol Res Ctr, Herbarium Bogeriense, Bogor, Indonesia

[3] Indonesian Inst Sci, Res Ctr Chem, Serpong 15310, Tangerang, Indonesia

[4] Univ Illinois, Program Collaborat Res Pharmaceut Sci, Chicago, IL 60612 USA

[5] Univ Illinois, Coll Pharm, Dept Med Chem & Pharmacognosy, Chicago, IL 60612 USA

来源：

PHYTOTHERAPY RESEARCH | 2006年 / 20卷 / 01期

关键词：

Helicteres hirsuta; lignans; cytotoxic constituents; cancer cell lines;

D O I：

10.1002/ptr.1806

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Cytotoxicity-guided fractionation of the stems of Helicteres hirsuta, of Indonesian origin, led to the isolation and identification of six lignans, namely, (+/-)-pinoresinol, (+/-)-medioresinol, (+/-)-syringaresinol, (-)-boehmenan, (-)-bochmenan H and (+/-)-trans-dihydrodiconiferyl alcohol. Of these isolates, ()-pinoresinol exhibited potent cytotoxic effects when evaluated against a small panel of cancer cell lines. Copyright (c) 2006 John Wiley & Sons, Ltd.

引用

页码：62 / 65

页数：4

共 38 条

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