Clinical and serological evolution in chronic Chagas disease patients in a 4-year pharmacotherapy follow-up: a preliminary study

被引：21

作者：

Andrade, Monica Coelho ^{[1
]}

Oliveira, Maria de Fatima ^{[2
]}

Nagao-Dias, Aparecida Tiemi ^{[2
]}

Branco Coelho, Ivo Castelo ^{[1
]}

Candido, Darlan da Silva ^{[2
]}

Freitas, Erlane Chaves ^{[1
]}

Luna Coelho, Helena Lutescia ^{[3
]}

Moraes Bezerra, Fernando Schemelzer ^{[1
,2
,4
]}

机构：

[1] Univ Fed Ceara, Fac Med, Dept Patol & Med Legal, Fortaleza, Ceara, Brazil

[2] Univ Fed Ceara, Fac Farm, Dept Anal Clin & Toxicol, Fortaleza, Ceara, Brazil

[3] Univ Fed Ceara, Fac Farm, Dept Farm, Fortaleza, Ceara, Brazil

[4] Univ Fed Ceara, Fac Med, Dept Saude Comunitaria, Fortaleza, Ceara, Brazil

来源：

REVISTA DA SOCIEDADE BRASILEIRA DE MEDICINA TROPICAL | 2013年 / 46卷 / 06期

关键词：

Benznidazole; Chagas disease; Pharmacotherapy follow-up;

D O I：

10.1590/0037-8682-1646-2013

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Introduction: The role of trypanocidal therapy in the chronic phase of Chagas disease remains controversial. Methods: A total of 13 patients with chronic Chagas disease were treated with benznidazole (5mg/kg/day/60 days) and surveyed via antibody measurement and conventional electrocardiogram over the course of 4 years. Results: The antibody titers were signifi cantly reduced after 4 years (p<0.05). Most of the patients showed maintenance of the initial clinical picture (electrocardiographic), with the exception of 4 cases. Conclusions: Although trypanocidal therapy in the chronic phase of Chagas disease was of limited effectiveness, we believe that it is benefi cial in treating these patients.

引用

页码：776 / 778

页数：3