The small GTPase Rab5 homologue Ypt5 regulates cell morphology, sexual development, ion-stress response and vacuolar formation in fission yeast

被引：6

作者：

Tsukamoto, Yuta ^{[1
]}

Katayama, Chisako ^{[1
]}

Shinohara, Miki ^{[2
]}

Shinohara, Akira ^{[2
]}

Maekawa, Shohei ^{[1
]}

Miyamoto, Masaaki ^{[1
,3
]}

机构：

[1] Kobe Univ, Grad Sch Sci, Kobe, Hyogo 6578501, Japan

[2] Osaka Univ, Inst Prot Res, Suita, Osaka 5650871, Japan

[3] Kobe Univ, Ctr Supports Res & Educ Act, Kobe, Hyogo 6578501, Japan

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2013年 / 441卷 / 04期

基金：

日本学术振兴会;

关键词：

Rab5; Fission yeast; A small GTPase; SCHIZOSACCHAROMYCES-POMBE; PROTEIN-TRANSPORT; IN-VITRO; LOCALIZATION; FUSION; PATHWAYS; ACTIN;

D O I：

10.1016/j.bbrc.2013.10.158

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Inner-membrane transport is critical to cell function. Rab family GTPases play an important role in vesicle transport. In mammalian cells, Rab5 is reported to be involved in the regulation of endosome formation, phagocytosis and chromosome alignment. Here, we examined the role of the fission yeast Rab5 homologue Ypt5 using a point mutant allele. Mutant cells displayed abnormal cell morphology, mating, sporulation, endocytosis, vacuole fusion and responses to ion stress. Our data strongly suggest that fission yeast Rab5 is involved in the regulation of various types of cellular functions. (C) 2013 Elsevier Inc. All rights reserved.

引用

页码：867 / 872

页数：6

共 4 条

[1] The small GTPase Rab5 controls cell morphology, sexual development, ion-stress response and vacuolar formation in fission yeast
Miyamoto, Masaaki
Tsukamoto, Yuta
Katayama, Chisako
Shinohara, Miki
Shinohara, Akira
Maekawa, Shohei
FASEB JOURNAL, 2014, 28 (01):
[2] The Nutrient Stress-induced Small GTPase Rab5 Contributes to the Activation of Vesicle Trafficking and Vacuolar Activity
Nakatsukasa, Kunio
Kanada, Akira
Matsuzaki, Mariko
Byrne, Stuart D.
Okumura, Fumihiko
Kamura, Takumi
JOURNAL OF BIOLOGICAL CHEMISTRY, 2014, 289 (30) : 20970 - 20978
[3] Small GTPase Rho5 is a functional homologue of Rho1, which controls cell shape and septation in fission yeast
Nakano, K
Arai, R
Mabuchi, I
FEBS LETTERS, 2005, 579 (23): : 5181 - 5186
[4] Coordinated regulation by two VPS9 domain-containing guanine nucleotide exchange factors in small GTPase Rab5 signaling pathways in fission yeast
Tsukamoto, Yuta
Kagiwada, Satoshi
Shimazu, Sayuri
Takegawa, Kaoru
Noguchi, Tetsuko
Miyamoto, Masaaki
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2015, 458 (04) : 802 - 809

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