Solid-Supported Iodonium Salts for Fluorinations

被引：16

作者：

Edwards, Richard ^{[1
]}

de Vries, Wilke ^{[1
]}

Westwell, Andrew D. ^{[2
]}

Daniels, Stephen ^{[3
]}

Wirth, Thomas ^{[1
]}

机构：

[1] Cardiff Univ, Sch Chem, Cardiff CF10 3AT, S Glam, Wales

[2] Cardiff Univ, Sch Pharm & Pharmaceut Sci, Cardiff CF10 3NB, S Glam, Wales

[3] Cardiff Univ, Sch Med, Wales Res & Diagnost PET Imaging Ctr PETIC, Cardiff CF14 4XN, S Glam, Wales

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2015年 / 2015卷 / 31期

关键词：

Solid-phase synthesis; Radiochemistry; Fluorine; Fluorination; Iodine; Hypervalent iodine; DIARYLIODONIUM-SALTS; ROUTE;

D O I：

10.1002/ejoc.201500992

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Solid-supported iodonium salt precursors have been prepared and used for the production of fluoroarenes. The importance of the resin functionality for the attachment of the iodonium salt moieties has been demonstrated. Furthermore, the production of new iodonium salt precursors for fluorination has been achieved by an alternative and improved method with respect to those previously described. The successful radiofluorination of a simple solid-supported precursor with no-carrier-added (n.c.a.) [F-18]fluoride shows the suitability of the method for the production of useful PET synthons.

引用

页码：6909 / 6916

页数：8

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