Hollow Metallic Micromachined Needle Arrays

被引:21
作者
Brazzle, John D. [1 ]
Papautsky, Ian [1 ]
Frazier, A. Bruno [2 ]
机构
[1] Univ Utah, Dept Bioengn, Salt Lake City, UT 84112 USA
[2] Georgia Inst Technol, Sch Elect & Comp Engn, Atlanta, GA 30332 USA
关键词
microneedles; microfluidics; micromachining; micro-electrodeposition; drug delivery;
D O I
10.1023/A:1009980412628
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
In this paper, fluid coupled metallic micromachined needle arrays are designed, fabricated, packaged, and characterized. The described hollow metallic needle arrays include design features such as dual structural supports and needle coupling channels. The supports and needle walls are formed by micro-electroformed metal to provide increased structural integrity. The needle coupling channels are used to fluidically interconnect the needles and allow pressure equalization and balance of fluid flow between needles. In addition, the needle coupling channels minimize the effects of restricted needle passages by providing a redistribution point for fluid flow between them. The optimum design for the needle coupling channels is investigated using an ANSYS finite element numerical model. The significance of this work includes the development of hollow, metallic micromachined needle arrays for biomedical applications, as well as, a discussion of structural, fluidic, and biological design considerations
引用
收藏
页码:197 / 205
页数:9
相关论文
共 29 条
  • [1] [Anonymous], [No title captured]
  • [2] [Anonymous], INTEGRATED CIRCUIT F
  • [3] [Anonymous], Patent Number, Patent No. [5,876,582, 5876582]
  • [4] Black J., 1999, BIOLOGICAL PERFORMAN
  • [5] Controlled liquid dosing in micro-instruments
    Boillat, M
    van der Schoot, B
    Arquint, P
    de Rooij, N
    [J]. MICROFLUIDIC DEVICES AND SYSTEMS II, 1999, 3877 : 20 - 27
  • [6] Brazzle John D., 1998, P SPIE MICR FLUID DE, P116
  • [7] An integrated nanoliter DNA analysis device
    Burns, MA
    Johnson, BN
    Brahmasandra, SN
    Handique, K
    Webster, JR
    Krishnan, M
    Sammarco, TS
    Man, PM
    Jones, D
    Heldsinger, D
    Mastrangelo, CH
    Burke, DT
    [J]. SCIENCE, 1998, 282 (5388) : 484 - 487
  • [8] Chen J., 1994, IEEE SOL STAT SENS A, P256
  • [9] Choi J.W., 1999, P EUR 13 NETH SEPT
  • [10] Cramer S.D., 1969, PLATING, P516