Bone Loss in Rheumatoid Arthritis: Systemic, Periarticular, and Focal

被引：80

作者：

Deal, Chad ^{[1
,2
]}

机构：

[1] Cleveland Clin, Lerner Coll Med Case Western, Univ Sch Med, Ctr Osteoporosis & Metab Bone Dis, Cleveland, OH 44122 USA

[2] Cleveland Clin, Lerner Coll Med Case Western, Univ Sch Med, Orthopaed & Rheumatol Inst, Cleveland, OH 44122 USA

来源：

CURRENT RHEUMATOLOGY REPORTS | 2012年 / 14卷 / 03期

关键词：

Osteoporosis; FRAX; Periarticular osteopenia; Marginal erosions; Wnt signaling; RANK ligand; Inflammation; Osteoimmunology; Osteoblasts; Osteoclasts; Magnetic resonance imaging; MRI; Bone loss; Rheumatoid arthritis; Systemic; Periarticular; Focal; MINERAL DENSITY; TNF-ALPHA; INFLAMMATORY ARTHRITIS; ESTROGEN DEFICIENCY; DISEASE-ACTIVITY; IMMUNE-SYSTEM; MARROW EDEMA; RESORPTION; OSTEOIMMUNOLOGY; METABOLISM;

D O I：

10.1007/s11926-012-0253-7

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Rheumatoid arthritis is a chronic inflammatory disease that results in generalized bone loss and increased fracture risk. Characteristic radiologic features of rheumatoid arthritis include periarticular osteopenia and marginal erosions. An emerging literature highlights the importance of osteoclasts as mediators of the erosive process, with an impairment of bone formation by inhibition of the Wnt signaling pathway as a cause of lack of repair of erosions. MRI has demonstrated the importance of inflammation in the bone marrow compartment as a cause of periarticular osteopenia. The term osteoimmunology has evolved to highlight the association between cells and cytokines of the immune system and their relationship to bone metabolism in rheumatoid arthritis and other forms of chronic inflammatory arthritis.

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页码：231 / 237

页数：7

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