Topological insulator bismuth selenide as a theranostic platform for simultaneous cancer imaging and therapy

被引：154

作者：

Li, Juan ^{[1
]}

Jiang, Fei ^{[2
]}

Yang, Bo ^{[2
]}

Song, Xiao-Rong ^{[1
]}

Liu, Yan ^{[3
]}

Yang, Huang-Hao ^{[1
]}

Cao, Dai-Rong ^{[2
]}

Shi, Wen-Rong ^{[3
]}

Chen, Guo-Nan ^{[1
]}

机构：

[1] Fuzhou Univ, Coll Chem & Chem Engn, Fujian Prov Key Lab Anal & Detect Technol Food Sa, Key Lab Anal & Detect Technol Food Safety MOE, Fuzhou 350002, Peoples R China

[2] Fujian Med Univ, Affiliated Hosp 1, Dept Radiol, Fuzhou 350005, Peoples R China

[3] Fujian Univ Tradit Chinese Med, Coll Integrated Tradit Chinese & Western Med, Fuzhou 350108, Peoples R China

来源：

SCIENTIFIC REPORTS | 2013年 / 3卷

基金：

中国国家自然科学基金; 美国国家科学基金会;

关键词：

INFRARED PHOTOTHERMAL THERAPY; CARBON NANOTUBES; CONVERSION EFFICIENCY; SURFACE-CHEMISTRY; GRAPHENE OXIDE; NANOPARTICLES; ABLATION; AGENT; DESIGN; GOLD;

D O I：

10.1038/srep01998

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Employing theranostic nanoparticles, which combine both therapeutic and diagnostic capabilities in one dose, has promise to propel the biomedical field toward personalized medicine. Here we investigate the theranostic properties of topological insulator bismuth selenide (Bi2Se3) in in vivo and in vitro system for the first time. We show that Bi2Se3 nanoplates can absorb near-infrared (NIR) laser light and effectively convert laser energy into heat. Such photothermal conversion property may be due to the unique physical properties of topological insulators. Furthermore, localized and irreversible photothermal ablation of tumors in the mouse model is successfully achieved by using Bi2Se3 nanoplates and NIR laser irradiation. In addition, we also demonstrate that Bi2Se3 nanoplates exhibit strong X-ray attenuation and can be utilized for enhanced X-ray computed tomography imaging of tumor tissue in vivo. This study highlights Bi2Se3 nanoplates could serve as a promising platform for cancer diagnosis and therapy.

引用

页数：7

共 54 条

[1] Large-Scale Synthesis of Bi2S3 Nanodots as a Contrast Agent for In Vivo X-ray Computed Tomography Imaging [J].