Distinguishing Subtypes in Primary Progressive Aphasia: Application of the Sydney Language Battery

被引：166

作者：

Savage, Sharon ^{[1
,2
,3
]}

Hsieh, Sharpley ^{[1
,3
]}

Leslie, Felicity ^{[1
,3
]}

Foxe, David ^{[1
,3
]}

Piguet, Olivier ^{[1
,2
,3
]}

Hodges, John R. ^{[1
,2
,3
]}

机构：

[1] Univ New S Wales, Neurosci Res Australia, Sydney, NSW, Australia

[2] Univ New S Wales, Sch Med Sci, Sydney, NSW, Australia

[3] Univ New S Wales, ARC Ctr Excellence Cognit & Its Disorders, Sydney, NSW, Australia

来源：

DEMENTIA AND GERIATRIC COGNITIVE DISORDERS | 2013年 / 35卷 / 3-4期

基金：

英国医学研究理事会; 澳大利亚研究理事会;

关键词：

Primary progressive aphasia; Cognitive assessment; Clinical diagnosis; Naming; Word repetition; Semantic knowledge; ADDENBROOKES COGNITIVE EXAMINATION; SEMANTIC DEMENTIA; NONFLUENT APHASIA; 3; VARIANTS; PATTERNS; ATROPHY; MRI;

D O I：

10.1159/000346389

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Background/Aims: Primary progressive aphasia (PPA) comprises three main subtypes, varying in clinical features, patterns of brain atrophy, and underlying pathology. Differentiation of these variants is important for treatment and planning; however, simple, effective cognitive tests to aid diagnosis are lacking. This study introduces a new language battery - the SYDBAT (Sydney Language Battery) - to assist clinicians. Methods: Fifty-seven PPA patients and 54 age-and education-matched healthy controls were compared on naming, repetition, word comprehension, and semantic association subtests. Results: Significant group differences were found for all tasks, reflecting different language profiles for each group. Using discriminative function analysis, 80% of PPA cases were correctly classified from three SYDBAT scores, from which a simple diagnostic algorithm was defined. Conclusion: The SYDBAT is a fast and simple tool which provides a valuable adjunct to clinicians diagnosing PPA. Copyright (C) 2013 S. Karger AG, Basel

引用

页码：208 / 218

页数：11

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