Immunotherapy in Nonmelanoma Skin Cancer

被引：5
|
作者：
Bassas Freixas, P. [1 ]
Aparicio Espanol, G. [1 ]
Garcia-Patos Briones, V [1 ]
机构：
[1] Hosp Univ Vail dHebron, Serv Dermatol, Barcelona, Spain
来源：
ACTAS DERMO-SIFILIOGRAFICAS | 2019年 / 110卷 / 05期
关键词：
Nonmelanoma skin cancer; Immunotherapy; Programmed cell death protein 1 (PD-1); Programmed death ligand 1 (PD-L1); Cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4); SQUAMOUS-CELL CARCINOMA; LONG-TERM SURVIVAL; DEATH LIGAND; IPILIMUMAB; EXPRESSION; PEMBROLIZUMAB; REGRESSION; BLOCKADE; CTLA-4; PD-L2;
D O I：
10.1016/j.ad.2018.09.013
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Immunotherapy is emerging as a new and promising treatment for a great variety of tumors, including nonmelanoma skin cancer. Checkpoint inhibitors - antibodies that block proteins that regulate the immune system - mainly target the surface protein CTLA-4 (cytotoxic T-lymphocyte-associated antigen 4) and the PD-1/PD-L1 (programmed cell death protein 1/PD-ligand 1) axis. We review the CTLA-4 and PD-1/PD-L1 pathways and current evidence supporting checkpoint inhibitor therapy in the main types of nonmelanoma skin cancer. (C) 2018 AEDV. Published by Elsevier Espana, S.L.U. All rights reserved.
引用
收藏
页码：353 / 359
页数：7
相关论文
共 50 条
  • [41] Presurgical Curettage Improves Accuracy for Nonmelanoma Skin Cancer Excision
    Lin, Matthew J.
    Dubin, Danielle P.
    Giordano, Cerrene N.
    Khorasani, Hooman
    Kriegel, David A.
    JOURNAL OF CUTANEOUS MEDICINE AND SURGERY, 2019, 23 (06) : 617 - 623
  • [42] Clinicopathological Pattern of Nonmelanoma Skin Cancer in Kuwait: A Retrospective Study
    Almutairi, Rawan
    Al-Awadhi, Rana
    Al-Sabah, Humoud
    MEDICAL PRINCIPLES AND PRACTICE, 2024, 33 (02) : 133 - 138
  • [43] An overview of the medical management of nonmelanoma skin cancer
    Metterle, Lauren
    Russell, Jeffrey S.
    Patel, Nishit S.
    CURRENT PROBLEMS IN CANCER, 2015, 39 (04) : 226 - 236
  • [44] Merkel cell polyomavirus large T antigen is detected in rare cases of nonmelanoma skin cancer
    Mertz, Kirsten D.
    Paasinen, Aino
    Arnold, Andreas
    Baumann, Michele
    Offner, Felix
    Willi, Niels
    Cathomas, Gieri
    JOURNAL OF CUTANEOUS PATHOLOGY, 2013, 40 (06) : 543 - 549
  • [45] Updates in the Management of Advanced Nonmelanoma Skin Cancer
    Yan, Flora
    Schmalbach, Cecelia E.
    SURGICAL ONCOLOGY CLINICS OF NORTH AMERICA, 2024, 33 (04) : 723 - 733
  • [46] Nonmelanoma Skin Cancer After Kidney Transplant
    Tepeoglu, Merih
    Ayva, Sebnem
    Atilgan, Alev Ok
    Tunca, M. Zeyneb
    Ozdemir, B. Handan
    Moray, Gokhan
    Yildirim, Sedat
    Arslan, Gulnaz
    Haberal, Mehmet
    EXPERIMENTAL AND CLINICAL TRANSPLANTATION, 2014, 12 (03) : 233 - 237
  • [47] Noninvasive diagnostic tools for nonmelanoma skin cancer
    Ulrich, M.
    Stockfleth, E.
    Roewert-Huber, J.
    Astner, S.
    BRITISH JOURNAL OF DERMATOLOGY, 2007, 157 : 56 - 58
  • [48] Clinical prediction rule for nonmelanoma skin cancer
    Nova, John Alexander
    Sanchez, Guillermo
    Tejada, Constanza Eugenia
    CLINICAL CANCER INVESTIGATION JOURNAL, 2015, 4 (03): : 323 - 326
  • [49] Cancer immunotherapy: challenges and clinical applications
    Xia, An-Liang
    Xu, Yong
    Lu, Xiao-Jie
    JOURNAL OF MEDICAL GENETICS, 2019, 56 (01) : 1 - 3
  • [50] Programmed cell death 1 protein and programmed death-ligand 1 inhibitors in the treatment of nonmelanoma skin cancer: A systematic review
    Choi, Franchesca D.
    Kraus, Christina N.
    Elsensohn, Ashley N.
    Carley, Sama K.
    Lehmer, Larisa M.
    Nguyen, Rebecca T.
    Linden, Kenneth G.
    Shiu, Jessica
    JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2020, 82 (02) : 440 - 459
12345