Immunotherapy in Nonmelanoma Skin Cancer

被引：5
|
作者：
Bassas Freixas, P. [1 ]
Aparicio Espanol, G. [1 ]
Garcia-Patos Briones, V [1 ]
机构：
[1] Hosp Univ Vail dHebron, Serv Dermatol, Barcelona, Spain
来源：
ACTAS DERMO-SIFILIOGRAFICAS | 2019年 / 110卷 / 05期
关键词：
Nonmelanoma skin cancer; Immunotherapy; Programmed cell death protein 1 (PD-1); Programmed death ligand 1 (PD-L1); Cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4); SQUAMOUS-CELL CARCINOMA; LONG-TERM SURVIVAL; DEATH LIGAND; IPILIMUMAB; EXPRESSION; PEMBROLIZUMAB; REGRESSION; BLOCKADE; CTLA-4; PD-L2;
D O I：
10.1016/j.ad.2018.09.013
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Immunotherapy is emerging as a new and promising treatment for a great variety of tumors, including nonmelanoma skin cancer. Checkpoint inhibitors - antibodies that block proteins that regulate the immune system - mainly target the surface protein CTLA-4 (cytotoxic T-lymphocyte-associated antigen 4) and the PD-1/PD-L1 (programmed cell death protein 1/PD-ligand 1) axis. We review the CTLA-4 and PD-1/PD-L1 pathways and current evidence supporting checkpoint inhibitor therapy in the main types of nonmelanoma skin cancer. (C) 2018 AEDV. Published by Elsevier Espana, S.L.U. All rights reserved.
引用
收藏
页码：353 / 359
页数：7
相关论文
共 50 条
  • [31] An update on local and systemic therapies for nonmelanoma skin cancer
    Elleson, Kelly M.
    DePalo, Danielle K.
    Zager, Jonathan S.
    EXPERT REVIEW OF ANTICANCER THERAPY, 2022, 22 (05) : 479 - 489
  • [32] Immunotherapy for skin cancer
    Paulson, Kelly G.
    Lahman, Miranda C.
    Chapuis, Aude G.
    Brownell, Isaac
    INTERNATIONAL IMMUNOLOGY, 2019, 31 (07) : 465 - 475
  • [33] Genetics and nonmelanoma skin cancer in kidney transplant recipients
    Burke, Michael T.
    Isbel, Nicole
    Barraclough, Katherine A.
    Jung, Ji-Won
    Wells, James W.
    Staatz, Christine E.
    PHARMACOGENOMICS, 2015, 16 (02) : 161 - 172
  • [34] Surgical Outcomes for Nonmelanoma Skin Cancer of the Head and Neck
    Liu, Hua
    Dai, Xiaoming
    ANNALS OF PLASTIC SURGERY, 2025, 94 (04) : 443 - 446
  • [35] Nonsurgical Treatment of Nonmelanoma Skin Cancer
    Galiczynski, Edward M.
    Vidimos, Allison T.
    DERMATOLOGIC CLINICS, 2011, 29 (02) : 297 - +
  • [36] DNA ploidy in nonmelanoma skin cancer
    Robinson, JK
    Rademaker, AW
    Goolsby, C
    Traczyk, TN
    Zoladz, C
    CANCER, 1996, 77 (02) : 284 - 291
  • [37] Nonmelanoma Skin Cancer in Young Women
    Wu, Timothy P.
    Stein, Jennifer A.
    JOURNAL OF DRUGS IN DERMATOLOGY, 2013, 12 (05) : 568 - 572
  • [38] Nonmelanoma Skin Cancer of the Head and Neck Current Diagnosis and Treatment
    Eskiizmir, Gorkem
    Cingi, Cemal
    FACIAL PLASTIC SURGERY CLINICS OF NORTH AMERICA, 2012, 20 (04) : 415 - +
  • [39] Cancer Immunotherapy for the General Surgeon
    Fromer, Marc W.
    Scoggins, Charles R.
    AMERICAN SURGEON, 2020, 86 (04) : 284 - 292
  • [40] Histopathologic PD-L1 Tumor Expression and Prognostic Significance in Nonmelanoma Skin Cancers: A Systematic Review
    Lehmer, Larisa
    Choi, Franchesca
    Kraus, Christina
    Shiu, Jessica
    de Feraudy, Sebastien
    Elsensohn, Ashley
    AMERICAN JOURNAL OF DERMATOPATHOLOGY, 2021, 43 (05) : 321 - 330
12345