Immunotherapy in Nonmelanoma Skin Cancer

被引：5
|
作者：
Bassas Freixas, P. [1 ]
Aparicio Espanol, G. [1 ]
Garcia-Patos Briones, V [1 ]
机构：
[1] Hosp Univ Vail dHebron, Serv Dermatol, Barcelona, Spain
来源：
ACTAS DERMO-SIFILIOGRAFICAS | 2019年 / 110卷 / 05期
关键词：
Nonmelanoma skin cancer; Immunotherapy; Programmed cell death protein 1 (PD-1); Programmed death ligand 1 (PD-L1); Cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4); SQUAMOUS-CELL CARCINOMA; LONG-TERM SURVIVAL; DEATH LIGAND; IPILIMUMAB; EXPRESSION; PEMBROLIZUMAB; REGRESSION; BLOCKADE; CTLA-4; PD-L2;
D O I：
10.1016/j.ad.2018.09.013
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Immunotherapy is emerging as a new and promising treatment for a great variety of tumors, including nonmelanoma skin cancer. Checkpoint inhibitors - antibodies that block proteins that regulate the immune system - mainly target the surface protein CTLA-4 (cytotoxic T-lymphocyte-associated antigen 4) and the PD-1/PD-L1 (programmed cell death protein 1/PD-ligand 1) axis. We review the CTLA-4 and PD-1/PD-L1 pathways and current evidence supporting checkpoint inhibitor therapy in the main types of nonmelanoma skin cancer. (C) 2018 AEDV. Published by Elsevier Espana, S.L.U. All rights reserved.
引用
收藏
页码：353 / 359
页数：7
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