Facts and Hopes for Gut Microbiota Interventions in Cancer Immunotherapy

被引：27

作者：

Davar, Diwakar ^{[1
,2
]}

Zarour, Hassane M. ^{[1
,2
,3
,4
]}

机构：

[1] Univ Pittsburgh, Dept Med, Pittsburgh, PA USA

[2] Univ Pittsburgh, UPMC Hillman Canc Ctr, Pittsburgh, PA USA

[3] Univ Pittsburgh, Dept Immunol, Pittsburgh, PA USA

[4] UPMC Hillman Canc Ctr, 5117 Ctr Ave, Pittsburgh, PA 15213 USA

来源：

CLINICAL CANCER RESEARCH | 2022年 / 28卷 / 20期

关键词：

CHAIN FATTY-ACIDS; CD8(+) T-CELLS; IMMUNE CHECKPOINT INHIBITORS; FUSOBACTERIUM-NUCLEATUM; ANTI-PD-1; EFFICACY; ANTICANCER THERAPY; ANTITUMOR IMMUNITY; PANCREATIC-CANCER; DIETARY FIBER; LUNG-CANCER;

D O I：

10.1158/1078-0432.CCR-21-1129

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Immune checkpoint inhibitors (ICI) targeting cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) and programmed death 1 (PD-1) proteins transformed the management of advanced cancers. Many tumor-intrinsic factors modulate immunological and clinical responses to such therapies, but ample evidence also implicates the gut microbiome in responses. The gut microbiome, comprising the bacteria, archaea, fungi, and viruses that live in the human digestive tract, is an established determinant of host immunity, but its impact on response to ICI therapy in mice and humans with cancer has only recently been appreciated. Therapeutic interventions to optimize microbiota composition to improve immunotherapy outcomes show promise in mice and humans with cancer. In this review, we discuss the rationale for gut microbiome-based cancer therapies, the results from early-phase clinical trials, and possible future developments.

引用

页码：4370 / 4384

页数：15

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