Isolation and structural assignment of 5-deoxytetrodotoxin from the puffer fish Fugu poecilonotus

被引：41

作者：

Yotsu-Yamashita, M ^{[1
]}

Schimmele, B ^{[1
]}

Yasumoto, T ^{[1
]}

机构：

[1] Tohoku Univ, Grad Sch Agr, Aoba Ku, Sendai, Miyagi 9818555, Japan

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 1999年 / 63卷 / 05期

关键词：

5-deoxytetrodotoxin; structural assignment; biosynthetic pathway; puffer fish;

D O I：

10.1271/bbb.63.961

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A novel 10,7-lactone type of tetrodotoxin analog, 5-deoxytetrodotoxin, was isolated from the puffer fish, Fugu poecilonotus, and its structure was assigned by spectroscopic methods.

引用

页码：961 / 963

页数：3

共 12 条

[1]

BEECHAM AF, 1968, TETRAHEDRON LETT, P2355

[2] ISOLATION OF 11-NORTETRODOTOXIN-6(R)-OL AND OTHER TETRODOTOXIN DERIVATIVES FROM THE PUFFER FUGU-NIPHOBLES [J].

ENDO, A ;

KHORA, SS ;

MURATA, M ;

NAOKI, H ;

YASUMOTO, T .

TETRAHEDRON LETTERS, 1988, 29 (33) :4127-4128

[3] STRUCTURE-ACTIVITY RELATIONS OF TETRODOTOXIN, SAXITOXIN, AND ANALOGS [J].

KAO, CY .

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1986, 479 :52-67

[4] ISOLATION OF 11-OXOTETRODOTOXIN FROM THE PUFFER AROTHRON-NIGROPUNCTATUS [J].

KHORA, SS ;

YASUMOTO, T .

TETRAHEDRON LETTERS, 1989, 30 (33) :4393-4394

[5] 1-HYDROXY-5,11-DIDEOXYTETRODOTOXIN, THE 1ST N-HYDROXY AND RING-DEOXY DERIVATIVE OF TETRODOTOXIN FOUND IN THE NEWT TARICHA-GRANULOSA [J].

KOTAKI, Y ;

SHIMIZU, Y .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1993, 115 (03) :827-830

[6] THE CHEMISTRY OF TETRODOTOXIN [J].

MOSHER, HS .

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1986, 479 :32-43

[7] FLUOROMETRIC-DETERMINATION OF TETRODOTOXIN BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY [J].

YASUMOTO, T ;

MICHISHITA, T .

AGRICULTURAL AND BIOLOGICAL CHEMISTRY, 1985, 49 (10) :3077-3080

[8] NEW TETRODOTOXIN ANALOGS FROM THE NEWT CYNOPS-ENSICAUDA [J].

YASUMOTO, T ;

YOTSU, M ;

MURATA, M ;

NAOKI, H .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1988, 110 (07) :2344-2345

[9] ISOLATION AND STRUCTURAL ASSIGNMENT OF 11-NORTETRODOTOXIN-6(S)-OL FROM THE PUFFER AROTHRON-NIGROPUNCTATUS [J].

YOTSU, M ;

HAYASHI, Y ;

KHORA, SS ;

SATO, S ;

YASUMOTO, T .

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 1992, 56 (02) :370-371

[10] AN IMPROVED TETRODOTOXIN ANALYZER [J].

YOTSU, M ;

ENDO, A ;

YASUMOTO, T .

AGRICULTURAL AND BIOLOGICAL CHEMISTRY, 1989, 53 (03) :893-895

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