Cardio-Renal Syndrome Type 4: Epidemiology, Pathophysiology and Treatment

被引：23

作者：

House, Andrew A. ^{[1
,2
]}

机构：

[1] Univ Western Ontario, Div Nephrol, Schulich Sch Med & Dent, Univ Hosp, London, ON N6A 5A5, Canada

[2] Univ Hosp, London Hlth Sci Ctr, London, ON N6A 5A5, Canada

来源：

SEMINARS IN NEPHROLOGY | 2012年 / 32卷 / 01期

关键词：

Cardio-Renal syndrome; renocardiac syndrome; chronic kidney disease; cardiovascular disease; epidemiology; risk factors; CHRONIC KIDNEY-DISEASE; STAGE RENAL-DISEASE; C-REACTIVE PROTEIN; PLASMA TOTAL HOMOCYSTEINE; SYNDROMES WORKGROUP STATEMENTS; GLOMERULAR-FILTRATION-RATE; SUDDEN CARDIAC DEATH; CARDIOVASCULAR EVENTS; RISK-FACTORS; HEMODIALYSIS-PATIENTS;

D O I：

10.1016/j.semnephrol.2011.11.006

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Cardiovascular diseases such as coronary artery disease, congestive heart failure, arrhythmia, and sudden cardiac death represent the leading causes of morbidity and mortality in patients with CKD, increasing sharply as patients approach end-stage renal disease. The pathogenesis includes a complex, bidirectional interaction between the heart and kidneys that encompasses traditional and nontraditional risk factors, and has been termed cardio-renal syndrome type 4. In this review, an overview of the epidemiology and scope of this problem is provided, some suggested mechanisms for the pathophysiology of this disorder are discussed, and some of the key treatment strategies are described, with particular focus on recent clinical trials, both negative and positive. Semin Nephrol 32:40-48 (C) 2012 Elsevier Inc. All rights reserved.

引用

页码：40 / 48

页数：9

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