Frequency of autoantibodies and correlation with HLA-DRB1 genotype in sporadic inclusion body myositis (s-IBM): A population control study

被引：20

作者：

Rojana-udomsart, Arada ^{[1
,2
,3
]}

Bundell, Christine ^{[4
,5
]}

James, Ian ^{[6
]}

Castley, Alison ^{[7
]}

Martinez, Patricia ^{[5
,7
]}

Christiansen, Frank ^{[5
,7
]}

Hollingsworth, Peter ^{[4
,5
]}

Mastaglia, Frank ^{[1
,2
]}

机构：

[1] Univ Western Australia, Australian Neuromuscular Res Inst, Queen Elizabeth II Med Ctr, Perth, WA 6009, Australia

[2] Univ Western Australia, Ctr Neuromuscular & Neurol Disorders, Queen Elizabeth II Med Ctr, Perth, WA 6009, Australia

[3] Yala Hosp, Dept Med, Yala, Thailand

[4] Queen Elizabeth II Med Ctr, Dept Clin Immunol, PathWest, Perth, WA, Australia

[5] Univ Western Australia, Fac Med Dent & Hlth Sci, Sch Pathol & Lab Med, Perth, WA 6009, Australia

[6] Murdoch Univ, Ctr Clin Immunol & Biomed Stat, Inst Immunol & Infect Dis, Perth, WA, Australia

[7] Royal Perth Hosp, PathWest, Dept Clin Immunol, Perth, WA, Australia

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2012年 / 249卷 / 1-2期

关键词：

Inclusion body myositis; Autoantibodies; HLA-DRB1; alleles; IDIOPATHIC INFLAMMATORY MYOPATHIES; MAJOR HISTOCOMPATIBILITY COMPLEX; CLASS-II ALLELES; DISTINCT HLA-A; CELIAC-DISEASE; IMMUNOGENETIC FEATURES; PROTECTIVE FACTORS; ANTIBODIES; DIAGNOSIS; PROFILES;

D O I：

10.1016/j.jneuroim.2012.04.007

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The frequency of myositis-associated and myositis-specific autoantibodies (AAb) was compared in 51 s-IBM patients and a population control group. Non-organ specific AAb (ANA, anti-Ro52, anti-Ro60, anti-La, anti-RNP) but not anti-thyroid peroxidase, anti-tissue transglutaminase or myositis-specific antibodies, were more frequent in s-IBM patients, and 14/51 (27%) had another autoimmune disease (Sjogren's syndrome, thyroiditis, psoriasis, vitiligo). The presence of AAb did not correlate with carriage of HLA-DRB1*0301, but there was a negative correlation between ANA/anti-Ro52 and carriage of HLA-DRB1*1301. The findings in this cohort confirm that patients with sIBM do not show evidence of a muscle-specific humoral immune process but have an increased frequency of non-organ specific AAb and other autoimmune disorders. (C) 2012 Elsevier B.V. All rights reserved.

引用

页码：66 / 70

页数：5

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