The Role of Succinate in the Regulation of Intestinal Inflammation

被引：217

作者：

Connors, Jessica ^{[1
]}

Dawe, Nick ^{[2
]}

Van Limbergen, Johan ^{[1
,2
]}

机构：

[1] IWK Hlth Ctr, Div Gastroenterol, Halifax, NS B3K 6R8, Canada

[2] Dalhousie Univ, Dept Microbiol & Immunol, Halifax, NS B3H 4R2, Canada

来源：

NUTRIENTS | 2019年 / 11卷 / 01期

基金：

加拿大健康研究院;

关键词：

inflammatory bowel disease; microbiome; dysbiosis; metabolite; metabolic receptor; CHAIN FATTY-ACIDS; GUT MICROBIOTA; FUNCTIONAL-CHARACTERIZATION; CELL-PROLIFERATION; METABOLISM; HYPOXIA; GPR91; CYCLE; BUTYRATE; SIGNAL;

D O I：

10.3390/nu11010025

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Succinate is a metabolic intermediate of the tricarboxylic acid (TCA) cycle within host cells. Succinate is also produced in large amounts during bacterial fermentation of dietary fiber. Elevated succinate levels within the gut lumen have been reported in association with microbiome disturbances (dysbiosis), as well as in patients with inflammatory bowel disease (IBD) and animal models of intestinal inflammation. Recent studies indicate that succinate can activate immune cells via its specific surface receptor, succinate receptor 1(SUCNR1), and enhance inflammation. However, the role of succinate in inflammatory processes within the gut mucosal immune system is unclear. This review includes current literature on the association of succinate with intestinal inflammation and the potential role of succinate-SUCNR1 signaling in gut immune functions.

引用

页数：12

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