Visualizing breast cancer using the Twente photoacoustic mammoscope: What do we learn from twelve new patient measurements?

被引：157

作者：

Heijblom, M. ^{[1
,2
]}

Piras, D. ^{[1
]}

Xia, W. ^{[1
]}

van Hespen, J. C. G. ^{[1
]}

Klaase, J. M. ^{[2
]}

van den Engh, F. M. ^{[2
]}

van Leeuwen, T. G. ^{[1
,3
]}

Steenbergen, W. ^{[1
]}

Manohar, S. ^{[1
]}

机构：

[1] Univ Twente, Biomed Photon Imaging Grp, MIRA Inst Biomed Technol & Tech Med, NL-7500 AE Enschede, Netherlands

[2] Med Spectrum Twente Hosp, Ctr Breast Care, NL-7500 KA Enschede, Netherlands

[3] Univ Amsterdam, Acad Med Ctr, NL-1100 DE Amsterdam, Netherlands

来源：

OPTICS EXPRESS | 2012年 / 20卷 / 11期

关键词：

NIPPLE-AREOLA COMPLEX; OPTICAL TOMOGRAPHY; THERMOACOUSTIC TOMOGRAPHY; IMAGE-RECONSTRUCTION; DIAGNOSTIC-ACCURACY; TUMOR ANGIOGENESIS; PART I; MAMMOGRAPHY; SPECTROSCOPY; MR;

D O I：

10.1364/OE.20.011582

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

We acquired images of breast malignancies using the Twente photoacoustic mammoscope (PAM), to obtain more information about the clinical feasibility and limitations of photoacoustic mammography. Results were compared with conventional imaging and histopathology. Ten technically acceptable measurements on patients with malignancies and two measurements on patients with cysts were performed. In the reconstructed volumes of all ten malignant lesions, a confined region with high contrast with respect to the background could be seen. In all malignant cases, the PA contrast of the abnormality was higher than the contrast on x-ray mammography. The PA contrast appeared to be independent of the mammographically estimated breast density and was absent in the case of cysts. Technological improvements to the instrument and further studies on less suspicious lesions are planned to further investigate the potential of PAM. (C) 2012 Optical Society of America

引用

页码：11582 / 11597

页数：16

共 54 条

[1]

[Anonymous], 2013, ATLAS BREAST IMAGING

[2] Biomedical photoacoustic imaging [J].

Beard, Paul .

INTERFACE FOCUS, 2011, 1 (04) :602-631

[3] Diagnostic accuracy of mammography, clinical examination, US, and MR imaging in preoperative assessment of breast cancer [J].

Berg, WA ;

Gutierrez, L ;

NessAiver, MS ;

Carter, WB ;

Bhargavan, M ;

Lewis, RS ;

Ioffe, OB .

RADIOLOGY, 2004, 233 (03) :830-849

[4] Tumorigenesis and the angiogenic switch [J].

Bergers, G ;

Benjamin, LE .

NATURE REVIEWS CANCER, 2003, 3 (06) :401-410

[5] Near-infrared (NIR) tomography breast image reconstruction with a priori structural information from MRI:: Algorithm development for reconstructing heterogeneities [J].

Brooksby, BA ;

Dehghani, H ;

Pogue, BW ;

Paulsen, KD .

IEEE JOURNAL OF SELECTED TOPICS IN QUANTUM ELECTRONICS, 2003, 9 (02) :199-209

[6] Model-based optoacoustic inversions with incomplete projection data [J].

Buehler, Andreas ;

Rosenthal, Amir ;

Jetzfellner, Thomas ;

Dima, Alexander ;

Razansky, Daniel ;

Ntziachristos, Vasilis .

MEDICAL PHYSICS, 2011, 38 (03) :1694-1704

[7] Spectroscopy enhances the information content of optical mammography [J].

Cerussi, AE ;

Jakubowski, D ;

Shah, N ;

Bevilacqua, F ;

Lanning, R ;

Berger, AJ ;

Hsiang, D ;

Butler, J ;

Holcombe, RF ;

Tromberg, BJ .

JOURNAL OF BIOMEDICAL OPTICS, 2002, 7 (01) :60-71

[8] In vivo absorption, scattering, and physiologic properties of 58 malignant breast tumors determined by broadband diffuse optical spectroscopy [J].

Cerussi, Albert ;

Shah, Natasha ;

Hsiang, David ;

Durkin, Amanda ;

Butler, John ;

Tromberg, Bruce J. .

JOURNAL OF BIOMEDICAL OPTICS, 2006, 11 (04)

[9] Categorizing breast mammographic density: intra- and interobserver reproducibility of BI-RADS density categories [J].

Ciatto, S ;

Houssami, N ;

Apruzzese, A ;

Bassetti, E ;

Brancato, B ;

Carozzi, F ;

Catarzi, S ;

Lamberini, MP ;

Marcelli, G ;

Pellizzoni, R ;

Pesce, B ;

Risso, G ;

Russo, F ;

Scorsolini, A .

BREAST, 2005, 14 (04) :269-275

[10] Two-dimensional quantitative photoacoustic image reconstruction of absorption distributions in scattering media by use of a simple iterative method [J].

Cox, BT ;

Arridge, SR ;

Köstli, KP ;

Beard, PC .

APPLIED OPTICS, 2006, 45 (08) :1866-1875

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