A metal catalyst-free and one-pot synthesis of (3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)methanol derivatives in water

被引：4

作者：

Singh, Shambhu Nath ^{[1
,2
,3
]}

Jayaprakash, Sarva ^{[1
,2
]}

Reddy, K. Venkateshwara ^{[3
,4
]}

Nakhi, Ali ^{[5
]}

Pal, Manojit ^{[5
]}

机构：

[1] Custom Pharmaceut Serv, Hyderabad 500049, Andhra Pradesh, India

[2] Dr Reddys Labs Ltd, Hyderabad 500049, Andhra Pradesh, India

[3] JNT Univ, JNTUH Coll Engn, Dept Chem, Hyderabad 500085, Andhra Pradesh, India

[4] JNTU, CMR Engn Coll, Hyderabad 501401, Andhra Pradesh, India

[5] Dr Reddys Inst Life Sci, Hyderabad 500046, Andhra Pradesh, India

来源：

RSC ADVANCES | 2015年 / 5卷 / 103期

关键词：

3,4-DIHYDRO-2H-1,4-BENZOXAZINE DERIVATIVES; ANTITHROMBOTIC COMPOUNDS; DUAL FUNCTION; RECEPTOR; ANTAGONISTS; CHEMISTRY; DISCOVERY;

D O I：

10.1039/c5ra14478g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A robust and metal catalyst-free method has been developed for the general and green synthesis of racemic (3,4-dihydro-2H-benzo[b][1,4] oxazin-2-yl)methanol derivatives. This simple, mild and practical method involves the reaction of 2-aminophenols with (+/-)-epichlorohydrin in the presence of NaOH in water at room temperature. The reaction features high regioselectivity and a good substrate scope to produce both N-substituted and N-unsubstituted products.

引用

页码：84889 / 84893

页数：5

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