A metal catalyst-free and one-pot synthesis of (3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)methanol derivatives in water

被引：4

作者：

Singh, Shambhu Nath ^{[1
,2
,3
]}

Jayaprakash, Sarva ^{[1
,2
]}

Reddy, K. Venkateshwara ^{[3
,4
]}

Nakhi, Ali ^{[5
]}

Pal, Manojit ^{[5
]}

机构：

[1] Custom Pharmaceut Serv, Hyderabad 500049, Andhra Pradesh, India

[2] Dr Reddys Labs Ltd, Hyderabad 500049, Andhra Pradesh, India

[3] JNT Univ, JNTUH Coll Engn, Dept Chem, Hyderabad 500085, Andhra Pradesh, India

[4] JNTU, CMR Engn Coll, Hyderabad 501401, Andhra Pradesh, India

[5] Dr Reddys Inst Life Sci, Hyderabad 500046, Andhra Pradesh, India

来源：

RSC ADVANCES | 2015年 / 5卷 / 103期

关键词：

3,4-DIHYDRO-2H-1,4-BENZOXAZINE DERIVATIVES; ANTITHROMBOTIC COMPOUNDS; DUAL FUNCTION; RECEPTOR; ANTAGONISTS; CHEMISTRY; DISCOVERY;

D O I：

10.1039/c5ra14478g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A robust and metal catalyst-free method has been developed for the general and green synthesis of racemic (3,4-dihydro-2H-benzo[b][1,4] oxazin-2-yl)methanol derivatives. This simple, mild and practical method involves the reaction of 2-aminophenols with (+/-)-epichlorohydrin in the presence of NaOH in water at room temperature. The reaction features high regioselectivity and a good substrate scope to produce both N-substituted and N-unsubstituted products.

引用

页码：84889 / 84893

页数：5

共 50 条

[21] ZnO NANOPARTICLES AS AN EFFICIENT, HETEROGENEOUS, REUSABLE, AND ECOFRIENDLY CATALYST FOR ONE-POT, THREE-COMPONENT SYNTHESIS OF 3,4-DIHYDROPYRIMIDIN-2(1H)-(THIO)ONE DERIVATIVES IN WATER
Hassanpour, Akbar
Khanmiri, Rahim Hosseinzadeh
Abolhasani, Jafar
SYNTHETIC COMMUNICATIONS, 2015, 45 (06) : 737 - 743
[22] Synthesis, characterization and biological evaluation of 7-substituted-4-((1-aryl-1H-1,2,3-triazol-4-yl) methyl)-2H-benzo[b][1,4]oxazin-3(4H)-ones as anticancer agents
Nagavelli, Vasudeva Reddy
Nukala, Satheesh Kumar
Narsimha, Sirassu
Battula, Kumara Swamy
Tangeda, Savitha Jyostna
Reddy, Yellu Narasimha
MEDICINAL CHEMISTRY RESEARCH, 2016, 25 (09) : 1781 - 1793
[23] Metal Catalyst-free One-pot Synthesis of Carboxamide Derivatives via Ugi-4CC Reaction and its Anti-tubercular Study
Gondaliya, Bhumit L.
Sriram, Dharmarajan
Varakala, Saiprasad D.
Dholaria, Piyush V.
Dhuda, Gautam K.
Kapadiya, Khushal M.
LETTERS IN DRUG DESIGN & DISCOVERY, 2024, 21 (02) : 226 - 235
[24] Four-component, five-centered, one-pot synthesis of 1-(1H-tetrazol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole derivatives
Reddy, B. V. Subba
Kota, Kavya
Rao, B. Maheshwar
Sridhar, B.
Mukkanti, K.
TETRAHEDRON LETTERS, 2016, 57 (41) : 4529 - 4532
[25] A visible light-initiated, one-pot, multi-component synthesis of 2-amino-4-(5-hydroxy-3-methyl-1H-pyrazol-4-yl)-4H-chromene-3-carbonitrile derivatives under solvent- and catalyst-free conditions
Jaiswal, Deepali
Mishra, Anu
Rai, Pratibha
Srivastava, Madhulika
Tripathi, Bhartendu Pati
Yadav, Snehlata
Singh, Jaya
Singh, Jagdamba
RESEARCH ON CHEMICAL INTERMEDIATES, 2018, 44 (01) : 231 - 246
[26] Synthesis and Biological Evaluation of 3,4-Dihydro-3-(3-methylisoxazol-5-yl)-2H-benzo[e][1,3]oxazine Derivatives as Anticancer Agents
Kakkerla, Ramu
Marri, Srinivas
Krishna, M. P. S. Murali
Molgara, Parusharamulu
Reddy, Y. N.
LETTERS IN ORGANIC CHEMISTRY, 2018, 15 (02) : 124 - 132
[27] Solvent- and Catalyst-free Synthesis of (2-Amino-3-cyano-4H-chromen-4-yl) Phosphonates
Kumaraswamy, Gullapalli
Raghu, Nimmakayala
Kumar, Rangaraju Satish
ORGANIC PREPARATIONS AND PROCEDURES INTERNATIONAL, 2014, 46 (05) : 435 - 443
[28] A Straightforward and Efficient Catalyst-free One-pot Synthesis of N-Acyl-1,3-diary1-2-azaphenalene Derivatives via Multicomponent Reactions
Foroughifar, Naser
Mobinikhaledi, Akbar
Moghanian, Hassan
CHEMISTRY LETTERS, 2010, 39 (03) : 180 - 181
[29] One-Pot Three-Component Synthesis of Pyrido[2,3-c]carbazole Derivatives in EtOH under Catalyst-Free Conditions
Zhang, Mei-Mei
Wang, Jie
Wang, Xiang-Shan
JOURNAL OF HETEROCYCLIC CHEMISTRY, 2017, 54 (02) : 1378 - 1383
[30] Enantioselective One-Pot Synthesis of 2-Amino-4-(indol-3-yl)-4H-Chromenes
Chen, Weiliang
Cai, Yunfei
Fu, Xuan
Liu, Xiaohua
Lin, Lili
Feng, Xiaoming
ORGANIC LETTERS, 2011, 13 (18) : 4910 - 4913

← 1 2 3 4 5 →