Genetic variant in fat mass and obesity-associated gene associated with type 2 diabetes risk in Han Chinese

被引：16

作者：

Qian, Yun ^{[1
,2
]}

Liu, Sijun ^{[2
]}

Lu, Feng ^{[2
,3
]}

Li, Huizhang ^{[2
,4
]}

Dong, Meihua ^{[1
]}

Lin, Yudi ^{[1
]}

Du, Jiangbo ^{[2
]}

Lin, Yuan ^{[2
]}

Gong, Jianhang ^{[2
]}

Jin, Guangfu ^{[2
]}

Dai, Juncheng ^{[2
]}

Hu, Zhibin ^{[2
,5
]}

Shen, Hongbing ^{[2
,5
]}

机构：

[1] Wuxi Ctr Dis Control & Prevent, Dept Chron Noncommunicable Dis Control, Wuxi, Peoples R China

[2] Nanjing Med Univ, MOE Key Lab Modern Toxicol, Sch Publ Hlth, Dept Epidemiol & Biostat, Nanjing, Jiangsu, Peoples R China

[3] Zhejiang Prov Ctr Dis Control & Prevent, Dept Chron Noncommunicable Dis Control, Hangzhou, Zhejiang, Peoples R China

[4] Zhejiang Canc Hosp, Dept Canc Prevent & Treatment, Hangzhou, Zhejiang, Peoples R China

[5] Nanjing Med Univ, State Key Lab Reprod Med, Nanjing, Jiangsu, Peoples R China

来源：

BMC GENETICS | 2013年 / 14卷

基金：

中国国家自然科学基金;

关键词：

Fat mass and obesity-associated Gene; Genome-wide association study; Genetic susceptibility; Single nucleotide polymorphism; Type; 2; diabetes; GENOME-WIDE ASSOCIATION; FTO GENE; CDKAL1; CDKN2A/B; IGF2BP2; SLC30A8; HHEX; POLYMORPHISMS; METAANALYSIS; TCF7L2;

D O I：

10.1186/1471-2156-14-86

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Background: Genome-wide association study (GWAS) has identified that rs8050136 C/A polymorphism in fat mass and obesity-associated gene (FTO) was associated with the risk of type 2 diabetes (T2D) in Europeans. But this association was abolished after adjustment for body mass index (BMI), suggesting that the effect of rs8050136 on T2D risk might be mediated by BMI in Europeans. However, the findings in subsequent studies were inconsistent among Asian populations. To determine whether rs8050136 polymorphism in FTO is independently associated with the risk of T2D in Chinese, we conducted a case-control study with 2,925 T2D patients and 3,281 controls in Han Chinese. Results: Logistic regression revealed that the A allele of rs8050136 was significantly associated with an increased risk of T2D, independent of BMI (odds ratio (OR) = 1.17, 95% confidence interval (95% CI) = 1.03-1.32, p = 0.016). Meta-analysis containing 10 reported studies and our data with a total of 15,819 cases and 18,314 controls further confirmed the association between rs8050136 polymorphism and T2D risk in East Asians (OR = 1.13, 95% CI = 1.07-1.19). Conclusions: Our findings indicate that the genetic variant in FTO may

引用

页数：6

共 24 条

[1] FTO Is Increased in Muscle During Type 2 Diabetes, and Its Overexpression in Myotubes Alters Insulin Signaling, Enhances Lipogenesis and ROS Production, and Induces Mitochondrial Dysfunction [J].

Bravard, Amelie ;

Lefai, Etienne ;

Meugnier, Emmanuelle ;

Pesenti, Sandra ;

Disse, Emmanuel ;

Vouillarmet, Julien ;

Peretti, Noel ;

Rabasa-Lhoret, Remi ;

Laville, Martine ;

Vidal, Hubert ;

Rieusset, Jennifer .

DIABETES, 2011, 60 (01) :258-268

[2] Diabetes in Asia Epidemiology, Risk Factors, and Pathophysiology [J].

Chan, Juliana C. N. ;

Malik, Vasanti ;

Jia, Weiping ;

Kadowaki, Takashi ;

Yajnik, Chittaranjan S. ;

Yoon, Kun-Ho ;

Hu, Frank B. .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2009, 301 (20) :2129-2140

[3] A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity [J].

Frayling, Timothy M. ;

Timpson, Nicholas J. ;

Weedon, Michael N. ;

Zeggini, Eleftheria ;

Freathy, Rachel M. ;

Lindgren, Cecilia M. ;

Perry, John R. B. ;

Elliott, Katherine S. ;

Lango, Hana ;

Rayner, Nigel W. ;

Shields, Beverley ;

Harries, Lorna W. ;

Barrett, Jeffrey C. ;

Ellard, Sian ;

Groves, Christopher J. ;

Knight, Bridget ;

Patch, Ann-Marie ;

Ness, Andrew R. ;

Ebrahim, Shah ;

Lawlor, Debbie A. ;

Ring, Susan M. ;

Ben-Shlomo, Yoav ;

Jarvelin, Marjo-Riitta ;

Sovio, Ulla ;

Bennett, Amanda J. ;

Melzer, David ;

Ferrucci, Luigi ;

Loos, Ruth J. F. ;

Barroso, Ines ;

Wareham, Nicholas J. ;

Karpe, Fredrik ;

Owen, Katharine R. ;

Cardon, Lon R. ;

Walker, Mark ;

Hitman, Graham A. ;

Palmer, Colin N. A. ;

Doney, Alex S. F. ;

Morris, Andrew D. ;

Smith, George Davey ;

Hattersley, Andrew T. ;

McCarthy, Mark I. .

SCIENCE, 2007, 316 (5826) :889-894

[4] The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase [J].

Gerken, Thomas ;

Girard, Christophe A. ;

Tung, Yi-Chun Loraine ;

Webby, Celia J. ;

Saudek, Vladimir ;

Hewitson, Kirsty S. ;

Yeo, Giles S. H. ;

McDonough, Michael A. ;

Cunliffe, Sharon ;

McNeill, Luke A. ;

Galvanovskis, Juris ;

Rorsman, Patrik ;

Robins, Peter ;

Prieur, Xavier ;

Coll, Anthony P. ;

Ma, Marcella ;

Jovanovic, Zorica ;

Farooqi, I. Sadaf ;

Sedgwick, Barbara ;

Barroso, Ines ;

Lindahl, Tomas ;

Ponting, Chris P. ;

Ashcroft, Frances M. ;

O'Rahilly, Stephen ;

Schofield, Christopher J. .

SCIENCE, 2007, 318 (5855) :1469-1472

[5] Implication of genetic variants near SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, FTO, TCF2, KCNQ1, and WFS1 in Type 2 Diabetes in a Chinese population [J].

Han, Xueyao ;

Luo, Yingying ;

Ren, Qian ;

Zhang, Xiuying ;

Wang, Fang ;

Sun, Xiuqin ;

Zhou, Xianghai ;

Ji, Linong .

BMC MEDICAL GENETICS, 2010, 11

[6] FTO, Type 2 Diabetes, and Weight Gain Throughout Adult Life A Meta-Analysis of 41,504 Subjects From the Scandinavian HUNT, MDC, and MPP Studies [J].

Hertel, Jens K. ;

Johansson, Stefan ;

Sonestedt, Emily ;

Jonsson, Anna ;

Lie, Rolv T. ;

Platou, Carl G. P. ;

Nilsson, Peter M. ;

Rukh, Gull ;

Midthjell, Kristian ;

Hveem, Kristian ;

Melander, Olle ;

Groop, Leif ;

Lyssenko, Valeriya ;

Molven, Anders ;

Orho-Melander, Marju ;

Njolstad, Pal R. .

DIABETES, 2011, 60 (05) :1637-1644

[7] Variations in the HHEX gene are associated with increased risk of type 2 diabetes in the Japanese population [J].

Horikoshi, M. ;

Hara, K. ;

Ito, C. ;

Shojima, N. ;

Nagai, R. ;

Ueki, K. ;

Froguel, P. ;

Kadowaki, T. .

DIABETOLOGIA, 2007, 50 (12) :2461-2466

[8] PPARG, KCNJ11, CDKAL1, CDKN2A-CDKN2B, IDE-KIF11-HHEX, IGF2BP2 and SLC30A8 Are Associated with Type 2 Diabetes in a Chinese Population [J].

Hu, Cheng ;

Zhang, Rong ;

Wang, Congrong ;

Wang, Jie ;

Ma, Xiaojing ;

Lu, Jingyi ;

Qin, Wen ;

Hou, Xuhong ;

Wang, Chen ;

Bao, Yuqian ;

Xiang, Kunsan ;

Jia, Weiping .

PLOS ONE, 2009, 4 (10)

[9] Association between polymorphisms in SLC30A8, HHEX, CDKN2A/B, IGF2BP2, FTO, WFS1, CDKAL1, KCNQ1 and type 2 diabetes in the Korean population [J].

Lee, Yong-Ho ;

Kang, Eun Seok ;

Kim, So Hun ;

Han, Seung Jin ;

Kim, Chul Hoon ;

Kim, Hyeong Jin ;

Ahn, Chul Woo ;

Cha, Bong Soo ;

Nam, Moonsuk ;

Nam, Chung Mo ;

Lee, Hyun Chul .

JOURNAL OF HUMAN GENETICS, 2008, 53 (11-12) :991-998

[10] Association of genetic variation in FTO with risk of obesity and type 2 diabetes with data from 96,551 East and South Asians [J].

Li, H. ;

Kilpelaeinen, T. O. ;

Liu, C. ;

Zhu, J. ;

Liu, Y. ;

Hu, C. ;

Yang, Z. ;

Zhang, W. ;

Bao, W. ;

Cha, S. ;

Wu, Y. ;

Yang, T. ;

Sekine, A. ;

Choi, B. Y. ;

Yajnik, C. S. ;

Zhou, D. ;

Takeuchi, F. ;

Yamamoto, K. ;

Chan, J. C. ;

Mani, K. R. ;

Been, L. F. ;

Imamura, M. ;

Nakashima, E. ;

Lee, N. ;

Fujisawa, T. ;

Karasawa, S. ;

Wen, W. ;

Joglekar, C. V. ;

Lu, W. ;

Chang, Y. ;

Xiang, Y. ;

Gao, Y. ;

Liu, S. ;

Song, Y. ;

Kwak, S. H. ;

Shin, H. D. ;

Park, K. S. ;

Fall, C. H. D. ;

Kim, J. Y. ;

Sham, P. C. ;

Lam, K. S. L. ;

Zheng, W. ;

Shu, X. ;

Deng, H. ;

Ikegami, H. ;

Krishnaveni, G. V. ;

Sanghera, D. K. ;

Chuang, L. ;

Liu, L. ;

Hu, R. .

DIABETOLOGIA, 2012, 55 (04) :981-995

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