Common Protective Strategies in Neurodegenerative Disease: Focusing on Risk Factors to Target the Cellular Redox System

被引：37

作者：

Hrelia, Patrizia ^{[1
]}

Sita, Giulia ^{[1
]}

Ziche, Marina ^{[2
,3
]}

Ristori, Emma ^{[2
,3
]}

Marino, Angela ^{[4
]}

Cordaro, Marika ^{[5
]}

Molteni, Raffaella ^{[6
]}

Spero, Vittoria ^{[6
]}

Malaguti, Marco ^{[7
]}

Morroni, Fabiana ^{[1
]}

Hrelia, Silvana ^{[7
]}

机构：

[1] Univ Bologna, Dept Pharm & Biotechnol, Alma Mater Studiorum, I-40126 Bologna, Italy

[2] Univ Siena, Dept Med Sci Surg & Neurosci, I-53100 Siena, Italy

[3] Toscana Life Sci, I-53100 Siena, Italy

[4] Univ Messina, Dept Chem Biol Pharmaceut & Environm Sci, I-98166 Messina, Italy

[5] AOU Policlin Univ G Martino, Dept Biomed & Dent Sci & Morphofunct Imaging, I-98125 Messina, Italy

[6] Univ Milan, Dept Med Biotechnol & Translat Med, I-20129 Milan, Italy

[7] Univ Bologna, Dept Life Qual Studies, Alma Mater Studiorum, I-47900 Rimini, Italy

来源：

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY | 2020年 / 2020卷

关键词：

GLYCATION END-PRODUCTS; TRAUMATIC BRAIN-INJURY; AMYLOID PRECURSOR PROTEIN; BDNF MESSENGER-RNA; HEALTH-CARE PROFESSIONALS; TRANSIENT ISCHEMIC ATTACK; ALDEHYDE DEHYDROGENASE 2; EXCITATORY AMINO-ACIDS; OXIDATIVE STRESS; MOUSE MODEL;

D O I：

10.1155/2020/8363245

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Neurodegenerative disease is an umbrella term for different conditions which primarily affect the neurons in the human brain. In the last century, significant research has been focused on mechanisms and risk factors relevant to the multifaceted etiopathogenesis of neurodegenerative diseases. Currently, neurodegenerative diseases are incurable, and the treatments available only control the symptoms or delay the progression of the disease. This review is aimed at characterizing the complex network of molecular mechanisms underpinning acute and chronic neurodegeneration, focusing on the disturbance in redox homeostasis, as a common mechanism behind five pivotal risk factors: aging, oxidative stress, inflammation, glycation, and vascular injury. Considering the complex multifactorial nature of neurodegenerative diseases, a preventive strategy able to simultaneously target multiple risk factors and disease mechanisms at an early stage is most likely to be effective to slow/halt the progression of neurodegenerative diseases.

引用

页数：18

共 243 条

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