Ki67 and Salivary Cancer

被引：11

作者：

Ben-Izhak, Ofer ^{[1
]}

Akrish, Sharon ^{[1
]}

Nagler, Rafael M. ^{[1
,2
]}

机构：

[1] Rambam Med Ctr, Dept Pathol, Haifa, Israel

[2] Technion Israel Inst Technol, Bruce Rappaport Fac Med, Oral Biochem Lab, IL-31096 Haifa, Israel

来源：

CANCER INVESTIGATION | 2008年 / 26卷 / 10期

关键词：

Ki67; prognosis; malignancies; cancer; salivary glands;

D O I：

10.1080/07357900802088968

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We examined Ki67 expression in salivary malignancies of 75 patients with a follow-up period of up to 20 years. Correlations between enhanced Ki67 and enhanced p53 and TUNEL and heparanase staining levels were significant. Median survival for reduced-stained-tumor patients (<= 5%) was 163 months, dropping significantly to 39 months (p = 0.0005) for enhanced stained tumors (> 5%); 5 year survival probability was 93% and 33%, respectively, 45% and 16%, respectively, (p = 0.0005) at 20 years. Significant correlation between poor survival and concurrently altered expression rates of Ki67 and p53, p27 Skp2, TUNEL and heparanase in the salivary malignancies indicates a biological role in salivary cancer pathogenesis.

引用

页码：1015 / 1023

页数：9

共 25 条

[1] TUNEL - an efficient prognosis predictor of salivary malignancies [J].