A role for purinergic receptors at the inner hair cell-afferent synapse?

被引：16

作者：

Robertson, D ^{[1
]}

Paki, B ^{[1
]}

机构：

[1] Univ Western Australia, Dept Physiol, Auditory Lab, Nedlands, WA 6009, Australia

来源：

AUDIOLOGY AND NEURO-OTOLOGY | 2002年 / 7卷 / 01期

关键词：

suramin; PPADS; adenosine 5 '-triphosphate analogues; purinergic receptors; compound action potential; summating potential; single afferent neurons; spiral ganglion; spontaneous activity; tuning curves;

D O I：

10.1159/000046866

中图分类号：

R36 [病理学]; R76 [耳鼻咽喉科学];

学科分类号：

100104 ; 100213 ;

摘要：

Previously published evidence is reviewed for a functional role of ATP and its receptors at the chemical synapse between the mammalian inner hair cell and the primary afferent dendrites of the VIIIth nerve. New findings are also presented, both from gross cochlear potentials and single neurone recordings during intracochlear perfusion of ATP-receptor antagonists and agonists. Both the previous and present results are consistent with the notion that endogenous ATP may act to regulate the excitability of the primary afferent dendrite, possibly acting on P2X(2) receptors. Copyright (C) 2002 S. Karger AG, Basel.

引用

页码：62 / 67

页数：6

共 27 条

[1] Gene expression of P2X-receptors in the developing inner ear of the rat [J].

Brändle, U ;

Zenner, HP ;

Ruppersberg, JP .

NEUROSCIENCE LETTERS, 1999, 273 (02) :105-108

[2] Purinergic cotransmission [J].

Burnstock, G .

BRAIN RESEARCH BULLETIN, 1999, 50 (5-6) :355-357

[3] Additional pharmacological evidence that endogenous ATP modulates cochlear mechanics [J].

Chen, C ;

Skellett, RA ;

Fallon, M ;

Bobbin, RP .

HEARING RESEARCH, 1998, 118 (1-2) :47-61

[4] Functional expression of three P2X2 receptor splice variants from guinea pig cochlea [J].

Chen, C ;

Parker, MS ;

Barnes, AP ;

Deininger, P ;

Bobbin, RP .

JOURNAL OF NEUROPHYSIOLOGY, 2000, 83 (03) :1502-1509

[5]

Housley GD, 1998, J COMP NEUROL, V393, P403

[6] Extracellular nucleotide signaling in the inner ear [J].

Housley, GD .

MOLECULAR NEUROBIOLOGY, 1998, 16 (01) :21-48

[7] Physiological effects of extracellular nucleotides in the inner ear [J].

Housley, GD .

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 2000, 27 (08) :575-580

[8]

Housley GD, 1999, J NEUROSCI, V19, P8377

[9] A technique for slicing the rat cochlea around the onset of hearing [J].

Jagger, DJ ;

Robertson, D ;

Housley, GD .

JOURNAL OF NEUROSCIENCE METHODS, 2000, 104 (01) :77-86

[10]

Järlebark LE, 2000, J COMP NEUROL, V421, P289, DOI 10.1002/(SICI)1096-9861(20000605)421:3<289::AID-CNE1>3.0.CO

← 1 2 3 →