TNF-α increases breast cancer stem-like cells through up-regulating TAZ expression via the non-canonical NF-κB pathway

被引：97

作者：

Liu, Wenjing ^{[1
,2
,3
]}

Lu, Xiaoqing ^{[4
]}

Shi, Peiguo ^{[1
]}

Yang, Guangxi ^{[1
]}

Zhou, Zhongmei ^{[1
]}

Li, Wei ^{[3
,5
]}

Mao, Xiaoyun ^{[6
]}

Jiang, Dewei ^{[1
]}

Chen, Ceshi ^{[1
,7
]}

机构：

[1] Chinese Acad Sci, Key Lab Anim Models & Human Dis Mech, Chinese Acad Sci & Yunnan Prov, Kunming Inst Zool, Kunming 650223, Yunnan, Peoples R China

[2] Univ Chinese Acad Sci, Beijing 101407, Peoples R China

[3] Kunming Univ Sci & Technol, Med Fac, Kunming 650500, Yunnan, Peoples R China

[4] Shanxi Med Univ, Dept Breast Surg, Hosp 2, Taiyuan 030071, Peoples R China

[5] First Peoples Hosp Yunnan Prov, Dept Urol, Kunming 650032, Yunnan, Peoples R China

[6] China Med Univ, Affiliated Hosp 1, Breast Surg, Shenyang 110001, Peoples R China

[7] Chinese Acad Sci, Kunming Inst Zool, KIZ CUHK Joint Lab Bioresources & Mol Res Common, Kunming, Yunnan, Peoples R China

来源：

SCIENTIFIC REPORTS | 2020年 / 10卷 / 01期

关键词：

TUMOR-NECROSIS-FACTOR; GROWTH-FACTOR; TRANSCRIPTION; INFLAMMATION; PROLIFERATION; CONFERS; MEDIATE; CD44; CD24; GENE;

D O I：

10.1038/s41598-020-58642-y

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Breast cancer patients often suffer from disease relapse and metastasis due to the presence of breast cancer stem-like cells (BCSCs). Numerous studies have reported that high levels of inflammatory factors, including tumor necrosis factor alpha (TNF-alpha), promote BCSCs. However, the mechanism by which TNF-alpha promotes BCSCs is unclear. In this study, we demonstrate that TNF-alpha up-regulates TAZ, a transcriptional co-activator promoting BCSC self-renewal capacity in human breast cancer cell lines. Depletion of TAZ abrogated the increase in BCSCs mediated by TNF-alpha. TAZ is induced by TNF-alpha through the non-canonical NF-kappa B pathway, and our findings suggest that TAZ plays a crucial role in inflammatory factor-promoted breast cancer stemness and could serve as a promising therapeutic target.

引用

页数：11

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