Human neural stem cells express extra-neural markers

被引：26
作者：
Parati, EA
Bez, A
Ponti, D
de Grazia, U
Corsini, E
Cova, L
Sala, S
Colombo, A
Alessandri, G
Pagano, SF
机构：
[1] Natl Neurol Inst C Besta, Neuropharmacol Lab, I-20133 Milan, Italy
[2] ICP, Inst Obstet & Gynecol L Mangiagalli, I-20100 Milan, Italy
[3] Univ Brescia, Microbiol Lab, I-25123 Brescia, Italy
来源：
BRAIN RESEARCH | 2002年 / 925卷 / 02期
关键词：
human CNS stem cells; endothelial receptors; hematopoietic receptors; multipotent precursors; embryonic development;
D O I：
10.1016/S0006-8993(01)03291-7
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Neural stem cells can be derived from the adult/embryonic nervous system as well as from more primitive embryonic stem cells but, because of the lack of specific markers, only their differentiated progeny can be characterized. We here report the presence of several endothelial and hematopoietic receptors (at protein and mRNA level) on the surface of embryonic human neural stem cells, which are partially maintained during differentiation. This suggests that neural stem cells have a greater potential than previously thought, which involves the ability to respond to different and so far unconsidered environmental signals and may be responsible for the recently discovered process of stem cell-fate conversion. (C) 2002 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：213 / 221
页数：9
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