Antimicrobial susceptibility and molecular characteristics of 857 methicillin-resistant Staphylococcus aureus isolates from 16 medical centers in Japan (2008-2009): nationwide survey of community-acquired and nosocomial MRSA

被引：56

作者：

Yanagihara, Katsunori ^{[1
]}

Araki, Nobuko ^{[1
]}

Watanabe, Shinichi ^{[2
]}

Kinebuchi, Takahiro ^{[3
]}

Kaku, Mitsuo ^{[4
]}

Maesaki, Shigefumi ^{[5
]}

Yamaguchi, Keizo ^{[6
]}

Matsumoto, Tetsuya ^{[7
]}

Mikamo, Hiroshige ^{[8
]}

Takesue, Yoshio ^{[9
]}

Kadota, Jun-Ichi ^{[10
]}

Fujita, Jiro ^{[11
]}

Iwatsuki, Keiji ^{[12
]}

Hino, Haruko ^{[13
]}

Kaneko, Takehiko ^{[14
]}

Asagoe, Kenji ^{[15
]}

Ikeda, Masami ^{[16
]}

Yasuoka, Akira ^{[1
]}

Kohno, Shigeru ^{[1
]}

机构：

[1] Nagasaki Univ Hosp, Nagasaki 8528501, Japan

[2] Teikyo Univ, Sch Med, Dept Dermatol, Tokyo 1738606, Japan

[3] Social Welf Corp Hokkaido Inst Soc Frano Hosp, Dept Clin Lab, Sapporo, Hokkaido 0768765, Japan

[4] Tohoku Univ, Grad Sch Med, Dept Infect Control & Lab Diagnost, Sendai, Miyagi 9808574, Japan

[5] Saitama Med Univ Hosp, Saitama 3500495, Japan

[6] Toho Univ, Sch Med, Dept Microbiol & Infect Dis, Tokyo 1538515, Japan

[7] Tokyo Med Univ, Dept Infect Control & Prevent, Tokyo 1600023, Japan

[8] Aichi Med Univ, Dept Infect Control & Prevent, Aichi 4801195, Japan

[9] Hyogo Coll Med, Dept Infect Control & Prevent, Nishinomiya, Hyogo 6638501, Japan

[10] Oita Univ, Fac Med, Oita 8795593, Japan

[11] Univ Ryukyus, Dept Infect Resp & Digest Med Control & Prevent I, Fac Med, Okinawa 9030125, Japan

[12] Okayama Univ Hosp, Dept Dermatol, Okayama 7008558, Japan

[13] Kanto Cent Hosp, Dept Dermatol, Tokyo 1588531, Japan

[14] Fratern Mem Hosp, Dept Dermatol, Tokyo 1308587, Japan

[15] Okayama Med Ctr, Dept Dermatol, Okayama 7011192, Japan

[16] Takamatsu Red Cross Gen Hosp, Dept Dermatol, Kagawa 7600017, Japan

来源：

DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE | 2012年 / 72卷 / 03期

关键词：

MRSA; CA-MRSA; Nationwide survey; Antimicrobial susceptibility; Molecular characteristic; PCR ASSAY; HOSPITALS; ELEMENTS; GENES;

D O I：

10.1016/j.diagmicrobio.2011.11.010

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

This study is a nationwide survey of all clinical methicillin-resistant Staphylococcus aureus (MRSA) isolates, including community-acquired MRSA (CA-MRSA), in Japan. A total of 857 MRSA clinical isolates were collected from the 16 institutions throughout Japan that participated in the survey (2008-2009). The drug susceptibility and staphylococcal cassette chromosome mec (SCCmec) typing and the presence of specific pathogenic genes were evaluated. The isolates comprised SCCmec type II (73.6%), type IV (20%), and type I (6%). The percentage of SCCmec type IV isolates was significantly higher in outpatients than in inpatients. Most of the isolated strains were sensitive to vancomycin (VCM, MIC <= 2 mu g/mL), linezolid (MIC <= 4 mu g/mL), and teicoplanin (MIC <= 8 mu g/mL). Although most strains were sensitive to VCM, the MIC value of VCM for SCCmec type II strains was higher than that for SCCmec type IV strains. Only 4 (2.3%) of 171 SCCmec type IV strains were Panton-Valentine leukocidin (lukS/F-PV)-positive. Thus, this result indicates a unique feature of SCCmec type IV strains in Japan. The information in this study not only is important in terms of local public health but will also contribute to an understanding of epidemic clones of CA-MRSA. (C) 2012 Elsevier Inc. All rights reserved.

引用

页码：253 / 257

页数：5

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