Platelet Function and Signaling in Diabetes Mellitus

被引：19
作者：
Randriamboavonjy, Voahanginirina [1 ]
Fleming, Ingrid [1 ]
机构：
[1] Goethe Univ Frankfurt, Ctr Mol Med, Inst Vasc Signalling, D-60596 Frankfurt, Germany
来源：
CURRENT VASCULAR PHARMACOLOGY | 2012年 / 10卷 / 05期
关键词：
Atherothrombosis; calpain; chemokines; diabetes; platelets redox stress; SHORT-TERM HYPERGLYCEMIA; GLYCATION END-PRODUCTS; ACTIVATED PLATELETS; IN-VIVO; ENDOTHELIAL DYSFUNCTION; ADHESION MOLECULE-1; CD40; LIGAND; PHENOTYPIC MODULATION; RETICULUM CA2+-ATPASE; OXIDATIVE STRESS;
D O I：
10.2174/157016112801784639
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Diabetes mellitus is associated with the accelerated development of vascular disease and there is evidence that platelets actively contribute to this process. Certainly, platelets are able to modulate the function of endothelial and vascular smooth muscle cells via the direct release of growth factors and pro-inflammatory chemokines but also via the production of microparticles which function as a transcellular delivery system for micro RNAs. This article reviews the intracellular signaling mechanisms underlying the increased activation of diabetic platelets and the involvement of platelets in atherothrombosis development.
引用
收藏
页码：532 / 538
页数：7
相关论文
共 96 条
[1]   c-Src is required for oxidative stress-mediated activation of big mitogen-activated protein kinase 1 (BMK1) [J].
Abe, J ;
Takahashi, M ;
Ishida, M ;
Lee, JD ;
Berk, BC .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (33) :20389-20394
[2]   S-glutathiolation by peroxynitrite activates SERCA during arterial relaxation by nitric oxide [J].
Adachi, T ;
Weisbrod, RM ;
Pimentel, DR ;
Ying, J ;
Sharov, VS ;
Schöneich, C ;
Cohen, RA .
NATURE MEDICINE, 2004, 10 (11) :1200-1207
[3]   Antioxidant improves smooth muscle sarco/endoplasmic reticulum Ca2+-ATPase function and lowers tyrosine nitration in hypercholesterolemia and improves nitric oxide-induced relaxation [J].
Adachi, T ;
Matsui, R ;
Xu, SQ ;
Kirber, M ;
Lazar, HL ;
Sharov, VS ;
Schöneich, C ;
Cohen, RA .
CIRCULATION RESEARCH, 2002, 90 (10) :1114-1121
[4]   Aspirin resistance and diabetes mellitus [J].
Ajjan, R. ;
Storey, R. F. ;
Grant, P. J. .
DIABETOLOGIA, 2008, 51 (03) :385-390
[5]   AGONIST-INDUCED CA2+ INFLUX INTO HUMAN PLATELETS IS SECONDARY TO THE EMPTYING OF INTRACELLULAR CA2+ STORES [J].
ALONSO, MT ;
ALVAREZ, J ;
MONTERO, M ;
SANCHEZ, A ;
GARCIASANCHO, J .
BIOCHEMICAL JOURNAL, 1991, 280 :783-789
[6]   MicroRNA-132-mediated loss of p120RasGAP activates the endothelium to facilitate pathological angiogenesis [J].
Anand, Sudarshan ;
Majeti, Bharat K. ;
Acevedo, Lisette M. ;
Murphy, Eric A. ;
Mukthavaram, Rajesh ;
Scheppke, Lea ;
Huang, Miller ;
Shields, David J. ;
Lindquist, Jeffrey N. ;
Lapinski, Philip E. ;
King, Philip D. ;
Weis, Sara M. ;
Cheresh, David A. .
NATURE MEDICINE, 2010, 16 (08) :909-U109
[7]   A pharmacodynamic comparison of prasugrel vs. high-dose clopidogrel in patients with type 2 diabetes mellitus and coronary artery disease: results of the Optimizing anti-Platelet Therapy In diabetes MellitUS (OPTIMUS)-3 Trial [J].
Angiolillo, Dominick J. ;
JoseBadimon, Juan ;
Saucedo, Jorge F. ;
Frelinger, Andrew L. ;
Michelson, Alan D. ;
Jakubowski, Joseph A. ;
Zhu, Baojin ;
Ojeh, Clement K. ;
Baker, Brian A. ;
Effron, Mark B. .
EUROPEAN HEART JOURNAL, 2011, 32 (07) :838-846
[8]   Regulation of protein kinase C by short term hyperglycaemia in human platelets in vivo and in vitro [J].
Assert, R ;
Scherk, G ;
Bumbure, A ;
Pirags, V ;
Schatz, H ;
Pfeiffer, AFH .
DIABETOLOGIA, 2001, 44 (02) :188-195
[9]   MicroRNAs: Genomics, biogenesis, mechanism, and function (Reprinted from Cell, vol 116, pg 281-297, 2004) [J].
Bartel, David P. .
CELL, 2007, 131 (04) :11-29
[10]   At least 2 distinct pathways generating reactive oxygen species mediate vascular cell adhesion molecule-1 induction by advanced glycation end products [J].
Basta, G ;
Lazzerini, G ;
Del Turco, S ;
Ratto, GM ;
Schmidt, AM ;
De Caterina, R .
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2005, 25 (07) :1401-1407
12345678910