Precision medicine approaches for the management of Ewing sarcoma: current perspectives

被引：10

作者：

Rizk, Victoria T. ^{[1
]}

Walko, Christine M. ^{[2
]}

Brohl, Andrew S. ^{[3
,4
]}

机构：

[1] Univ S Florida, Tampa, FL 33620 USA

[2] DeBartolo Family Personalized Med Inst, Tampa, FL USA

[3] H Lee Moffitt Canc Ctr & Res Inst, Sarcoma Dept, 12902 Magnolia Dr, Tampa, FL 33612 USA

[4] H Lee Moffitt Canc Ctr & Res Inst, Chem Biol & Mol Med Program, Tampa, FL USA

来源：

PHARMACOGENOMICS & PERSONALIZED MEDICINE | 2019年 / 12卷

关键词：

Ewing sarcoma; next generation sequencing; genomics; liquid biopsy; targeted therapy; HUMAN MONOCLONAL-ANTIBODY; POLYMERASE-CHAIN-REACTION; SOFT-TISSUE SARCOMA; PHASE-II; GERMLINE MUTATIONS; PEDIATRIC-PATIENTS; PROGNOSTIC-FACTORS; GENOMIC LANDSCAPE; FAMILY TUMORS; BONE-MARROW;

D O I：

10.2147/PGPM.S170612

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Advancements in molecular and genetic techniques have significantly furthered our biological understanding of Ewing sarcoma (ES). ES is typified by a driving TET-ETS fusion with an otherwise relatively quiet genome. Detection of one of several characteristic fusions, most commonly EWSR1-FL11, is the gold standard for diagnosis. We discuss the current role of precision medicine in the diagnosis, treatment, and monitoring of ES. Continued efforts toward molecularly guided approaches are actively being pursued in ES to better refine prognosis, identify germline markers of disease susceptibility, influence therapeutic selection, effectively monitor disease activity in real time, and identify genetic and immunotherapeutic targets for therapeutic development.

引用

页码：9 / 14

页数：6

共 61 条

[1]

[Anonymous], J CLIN ONCOL S

[2] New Strategies in Ewing Sarcoma: Lost in Translation? [J].

Arnaldez, Fernanda I. ;

Helman, Lee J. .

CLINICAL CANCER RESEARCH, 2014, 20 (12) :3050-3056

[3] Use of reverse transcriptase polymerase chain reaction for diagnosis and staging of alveolar rhabdomyosarcoma, Ewing sarcoma family of tumors, and desmoplastic small round cell tumor [J].

Athale, UH ;

Shurtleff, SA ;

Jenkins, JJ ;

Poquette, CA ;

Tan, M ;

Downing, JR ;

Pappo, AS .

JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY, 2001, 23 (02) :99-104

[4] Monogenic and polygenic determinants of sarcoma risk: an international genetic study [J].

Ballinger, Mandy L. ;

Goode, David L. ;

Ray-Coquard, Isabelle ;

James, Paul A. ;

Mitchell, Gillian ;

Niedermayr, Eveline ;

Puri, Ajay ;

Schiffman, Joshua D. ;

Dite, Gillian S. ;

Cipponi, Arcadi ;

Maki, Robert G. ;

Brohl, Andrew S. ;

Myklebost, Ola ;

Stratford, Eva W. ;

Lorenz, Susanne ;

Ahn, Sung-Min ;

Ahn, Jin-Hee ;

Kim, Jeong Eun ;

Shanley, Sue ;

Beshay, Victoria ;

Randall, Robert Lor ;

Judson, Ian ;

Seddon, Beatrice ;

Campbell, Ian G. ;

Young, Mary-Anne ;

Sarin, Rajiv ;

Blay, Jean-Yves ;

O'Donoghue, Sean I. ;

Thomas, David M. .

LANCET ONCOLOGY, 2016, 17 (09) :1261-1271

[5] Frequent inactivating germline mutations in DNA repair genes in patients with Ewing sarcoma [J].

Brohl, Andrew S. ;

Patidar, Rajesh ;

Turner, Clesson E. ;

Wen, Xinyu ;

Song, Young K. ;

Wei, Jun S. ;

Calzone, Kathleen A. ;

Khan, Javed .

GENETICS IN MEDICINE, 2017, 19 (08) :955-958

[6] The Genomic Landscape of the Ewing Sarcoma Family of Tumors Reveals Recurrent STAG2 Mutation [J].

Brohl, Andrew S. ;

Solomon, David A. ;

Chang, Wendy ;

Wang, Jianjun ;

Song, Young ;

Sindiri, Sivasish ;

Patidar, Rajesh ;

Hurd, Laura ;

Chen, Li ;

Shern, Jack F. ;

Liao, Hongling ;

Wen, Xinyu ;

Gerard, Julia ;

Kim, Jung-Sik ;

Lopez Guerrero, Jose Antonio ;

Machado, Isidro ;

Wai, Daniel H. ;

Picci, Piero ;

Triche, Timothy ;

Horvai, Andrew E. ;

Miettinen, Markku ;

Wei, Jun S. ;

Catchpool, Daniel ;

Llombart-Bosch, Antonio ;

Waldman, Todd ;

Khan, Javed .

PLOS GENETICS, 2014, 10 (07)

[7] Phase II study of olaparib in patients with refractory Ewing sarcoma following failure of standard chemotherapy [J].

Choy, Edwin ;

Butrynski, James E. ;

Harmon, David C. ;

Morgan, Jeffrey A. ;

George, Suzanne ;

Wagner, Andrew J. ;

D'Adamo, David ;

Cote, Gregory M. ;

Flamand, Yael ;

Benes, Cyril H. ;

Haber, Daniel A. ;

Baselga, Jose M. ;

Demetri, George D. .

BMC CANCER, 2014, 14

[8] Prognostic factors in Ewing's tumor of bone:: Analysis of 975 patients from the European Intergroup Cooperative Ewing's Sarcoma Study group [J].

Cotterill, SJ ;

Ahrens, S ;

Paulussen, M ;

Jürgens, HF ;

Voûte, PA ;

Gadner, H ;

Craft, AW .

JOURNAL OF CLINICAL ONCOLOGY, 2000, 18 (17) :3108-3114

[9] The Genomic Landscape of Pediatric Ewing Sarcoma [J].

Crompton, Brian D. ;

Stewart, Chip ;

Taylor-Weiner, Amaro ;

Alexe, Gabriela ;

Kurek, Kyle C. ;

Calicchio, Monica L. ;

Kiezun, Adam ;

Carter, Scott L. ;

Shukla, Sachet A. ;

Mehta, Swapnil S. ;

Thorner, Aaron R. ;

de Torres, Carmen ;

Lavarino, Cinzia ;

Sunol, Mariona ;

McKenna, Aaron ;

Sivachenko, Andrey ;

Cibulskis, Kristian ;

Lawrence, Michael S. ;

Stojanov, Petar ;

Rosenberg, Mara ;

Ambrogio, Lauren ;

Auclair, Daniel ;

Seepo, Sara ;

Blumenstiel, Brendan ;

DeFelice, Matthew ;

Imaz-Rosshandler, Ivan ;

Schwarz-Cruz y Celis, Angela ;

Rivera, Miguel N. ;

Rodriguez-Galindo, Carlos ;

Fleming, Mark D. ;

Golub, Todd R. ;

Getz, Gad ;

Mora, Jaume ;

Stegmaier, Kimberly .

CANCER DISCOVERY, 2014, 4 (11) :1326-1341

[10]

CULLEN KJ, 1990, CANCER RES, V50, P48

← 1 2 3 4 5 6 7 →