Effects of salbutamol and Ro-20-1724 on airway and parenchymal mechanics in rats

被引:17
作者
Peták, F
Wale, JL
Sly, PD
机构
[1] Albert Szent Gyorgyi Med Univ, Dept Med Informat & Engn, H-6701 Szeged, Hungary
[2] Inst Child Hlth Res, Div Clin Sci, Perth, WA 6001, Australia
关键词
forced oscillation; airway resistance; tissue resistance; bronchodilators;
D O I
10.1152/jappl.1999.87.4.1373
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
We investigated the effects of a selective beta(2)-agonist, salbutamol, and of phosphodiesterase type 4 inhibition with 4-(3-butoxy-4-methoxy benzyl)-2-imidazolidinone (Ro-20-1724) on the airway and parenchymal mechanics during steady-state constriction induced by MCh administered as an aerosol or intravenously (iv). The wave-tube technique was used to measure the lung input impedance (ZL) between 0.5 and 20 Hz in 31 anesthetized, paralyzed, open-chest adult Brown Norway rats. To separate the airway and parenchymal responses, a model containing an airway resistance (Raw) and inertance (Iaw), and a parenchymal damping (G) and elastance (H), was fitted to ZL spectra under control conditions, during steady-state constriction, and after either salbutamol or Ro-20-1724 delivery. In the Brown Norway rat, the response to iv MCh infusion was seen in Raw and G, whereas continuous aerosolized MCh challenge produced increases in G and H only. Both salbutamol, administered either as an aerosol or iv, and Ro-20-1724 significantly reversed the increases in Raw and G when MCh was administered iv. During the MCh aerosol challenge, Ro-20-1724 significantly reversed the increases in G and H, whereas salbutamol had no effect. These results suggest that, after MCh-induced changes in lung function, salbutamol increases the airway caliber. Ro-20-1724 is effective in reversing the airway narrowings, and it may also decrease the parenchymal constriction.
引用
收藏
页码:1373 / 1380
页数:8
相关论文
共 34 条
[1]  
BARNES PJ, 1986, AM REV RESPIR DIS, V134, P1289
[2]   CYCLIC-NUCLEOTIDES AND PHOSPHODIESTERASES AND AIRWAY FUNCTION [J].
BARNES, PJ .
EUROPEAN RESPIRATORY JOURNAL, 1995, 8 (03) :457-462
[3]   COMPARISON OF DRUG-INDUCED RESPONSES ON RAT TRACHEAL, BRONCHIAL AND LUNG STRIP INVITRO PREPARATIONS [J].
BURNS, JW ;
DOE, JE .
BRITISH JOURNAL OF PHARMACOLOGY, 1978, 64 (01) :71-74
[4]  
CARSTAIRS JR, 1985, AM REV RESPIR DIS, V132, P541
[5]   MAPPING OF BETA-ADRENERGIC RECEPTORS IN RAT LUNG - EFFECT OF ISOPROTERENOL [J].
CONNER, MW ;
REID, LM .
EXPERIMENTAL LUNG RESEARCH, 1984, 6 (02) :91-101
[6]  
DICKINSON K, 1981, MOL PHARMACOL, V19, P194
[7]   CHARACTERIZATION AND AUTORADIOGRAPHIC DISTRIBUTION OF THE BETA-ADRENERGIC-RECEPTOR IN THE RAT LUNG [J].
FINKEL, MS ;
QUIRION, R ;
PERT, C ;
PATTERSON, RE .
PHARMACOLOGY, 1984, 29 (05) :247-254
[8]   TISSUE RESISTANCE AND THE CONTRACTILE STATE OF LUNG PARENCHYMA [J].
FREDBERG, JJ ;
BUNK, D ;
INGENITO, E ;
SHORE, SA .
JOURNAL OF APPLIED PHYSIOLOGY, 1993, 74 (03) :1387-1397
[9]   PHARMACOLOGICAL RESPONSES OF HUMAN AND PORCINE LUNG PARENCHYMA, BRONCHUS AND PULMONARY-ARTERY [J].
GOLDIE, RG ;
PATERSON, JW ;
WALE, JL .
BRITISH JOURNAL OF PHARMACOLOGY, 1982, 76 (04) :515-521
[10]   A COMPARATIVE-STUDY OF BETA-ADRENOCEPTORS IN HUMAN AND PORCINE LUNG PARENCHYMA STRIP [J].
GOLDIE, RG ;
PATERSON, JW ;
WALE, JL .
BRITISH JOURNAL OF PHARMACOLOGY, 1982, 76 (04) :523-526