Increasing evidence of a critical role played by the bronchial epithelium in airway homeostasis is opening new therapeutic avenues. Its unique situation at the interface with the environment suggests that the subtle regulation orchestrated by the epithelium between tolerance and specific immune response might be impaired in asthma. Airway mucus is acting as a physical and a biological fluid between the environment and the epithelium, synergistically moved by the cilia. In asthma, excessive mucus production is a hallmark of airway remodeling. Since many years we tried to therapeutically target mucus hypersecretion, but actually this option is still not achieved. The present review discusses the dynamic processes regulating airway mucus production. Airway inflammation is central in current asthma management Understanding of how the airway epithelium influences the TH2 paradigm in response to deleterious agents is improving. The multiple receptors expressed by the airway epithelium are the transducers of the biological signals induced by various invasive agents to develop the most adapted response. Airway remodeling is observed in severe chronic airway diseases and may result from ongoing disturbance of signal transduction and epithelial renewal. Chronic airway diseases such as asthma will require assessment of these epithelial abnormalities to identify phenotypic characteristics associated with predicting a clinical benefit for epithelial-directed therapies. (C) 2013 Elsevier Inc. All rights reserved.
机构:
SmithKline Beecham Pharmaceut, Dept Pulm Pharmacol, King Of Prussia, PA 19406 USASmithKline Beecham Pharmaceut, Dept Pulm Pharmacol, King Of Prussia, PA 19406 USA
机构:
SmithKline Beecham Pharmaceut, Dept Pulm Pharmacol, King Of Prussia, PA 19406 USASmithKline Beecham Pharmaceut, Dept Pulm Pharmacol, King Of Prussia, PA 19406 USA
机构:
Uppsala Univ, BMC, Dept Med Biochem & Microbiol, Uppsala, SwedenUppsala Univ, BMC, Dept Med Biochem & Microbiol, Uppsala, Sweden
Henningsson, Frida
;
Ding, Zhoujie
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h-index: 0
机构:
Uppsala Univ, BMC, Dept Med Biochem & Microbiol, Uppsala, SwedenUppsala Univ, BMC, Dept Med Biochem & Microbiol, Uppsala, Sweden
Ding, Zhoujie
;
Dahlin, Joakim S.
论文数: 0引用数: 0
h-index: 0
机构:
Uppsala Univ, BMC, Dept Med Biochem & Microbiol, Uppsala, SwedenUppsala Univ, BMC, Dept Med Biochem & Microbiol, Uppsala, Sweden
Dahlin, Joakim S.
;
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h-index:
机构:
Linkevicius, Marius
;
Carlsson, Fredrik
论文数: 0引用数: 0
h-index: 0
机构:
Uppsala Univ, Dept Immunol Pathol & Genet, Uppsala, SwedenUppsala Univ, BMC, Dept Med Biochem & Microbiol, Uppsala, Sweden
Carlsson, Fredrik
;
Gronvik, Kjell-Olov
论文数: 0引用数: 0
h-index: 0
机构:
Uppsala Univ, BMC, Dept Med Biochem & Microbiol, Uppsala, Sweden
Natl Vet Inst, S-75007 Uppsala, SwedenUppsala Univ, BMC, Dept Med Biochem & Microbiol, Uppsala, Sweden
Gronvik, Kjell-Olov
;
Hallgren, Jenny
论文数: 0引用数: 0
h-index: 0
机构:
Uppsala Univ, BMC, Dept Med Biochem & Microbiol, Uppsala, SwedenUppsala Univ, BMC, Dept Med Biochem & Microbiol, Uppsala, Sweden
Hallgren, Jenny
;
Heyman, Birgitta
论文数: 0引用数: 0
h-index: 0
机构:
Uppsala Univ, BMC, Dept Med Biochem & Microbiol, Uppsala, SwedenUppsala Univ, BMC, Dept Med Biochem & Microbiol, Uppsala, Sweden
机构:
SmithKline Beecham Pharmaceut, Dept Pulm Pharmacol, King Of Prussia, PA 19406 USASmithKline Beecham Pharmaceut, Dept Pulm Pharmacol, King Of Prussia, PA 19406 USA
机构:
SmithKline Beecham Pharmaceut, Dept Pulm Pharmacol, King Of Prussia, PA 19406 USASmithKline Beecham Pharmaceut, Dept Pulm Pharmacol, King Of Prussia, PA 19406 USA
机构:
Uppsala Univ, BMC, Dept Med Biochem & Microbiol, Uppsala, SwedenUppsala Univ, BMC, Dept Med Biochem & Microbiol, Uppsala, Sweden
Henningsson, Frida
;
Ding, Zhoujie
论文数: 0引用数: 0
h-index: 0
机构:
Uppsala Univ, BMC, Dept Med Biochem & Microbiol, Uppsala, SwedenUppsala Univ, BMC, Dept Med Biochem & Microbiol, Uppsala, Sweden
Ding, Zhoujie
;
Dahlin, Joakim S.
论文数: 0引用数: 0
h-index: 0
机构:
Uppsala Univ, BMC, Dept Med Biochem & Microbiol, Uppsala, SwedenUppsala Univ, BMC, Dept Med Biochem & Microbiol, Uppsala, Sweden
Dahlin, Joakim S.
;
论文数: 引用数:
h-index:
机构:
Linkevicius, Marius
;
Carlsson, Fredrik
论文数: 0引用数: 0
h-index: 0
机构:
Uppsala Univ, Dept Immunol Pathol & Genet, Uppsala, SwedenUppsala Univ, BMC, Dept Med Biochem & Microbiol, Uppsala, Sweden
Carlsson, Fredrik
;
Gronvik, Kjell-Olov
论文数: 0引用数: 0
h-index: 0
机构:
Uppsala Univ, BMC, Dept Med Biochem & Microbiol, Uppsala, Sweden
Natl Vet Inst, S-75007 Uppsala, SwedenUppsala Univ, BMC, Dept Med Biochem & Microbiol, Uppsala, Sweden
Gronvik, Kjell-Olov
;
Hallgren, Jenny
论文数: 0引用数: 0
h-index: 0
机构:
Uppsala Univ, BMC, Dept Med Biochem & Microbiol, Uppsala, SwedenUppsala Univ, BMC, Dept Med Biochem & Microbiol, Uppsala, Sweden
Hallgren, Jenny
;
Heyman, Birgitta
论文数: 0引用数: 0
h-index: 0
机构:
Uppsala Univ, BMC, Dept Med Biochem & Microbiol, Uppsala, SwedenUppsala Univ, BMC, Dept Med Biochem & Microbiol, Uppsala, Sweden