Octacosanol and policosanol prevent high-fat diet-induced obesity and metabolic disorders by activating brown adipose tissue and improving liver metabolism

被引：56

作者：

Sharma, Rahul ^{[1
]}

Matsuzaka, Takashi ^{[1
,2
]}

Kaushik, Mahesh K. ^{[3
]}

Sugasawa, Takehito ^{[1
]}

Ohno, Hiroshi ^{[1
]}

Wang, Yunong ^{[1
]}

Motomura, Kaori ^{[1
]}

Shimura, Takuya ^{[1
]}

Okajima, Yuka ^{[1
]}

Mizunoe, Yuhei ^{[1
]}

Ma, Yang ^{[1
]}

Saber, Zahara M. ^{[1
]}

Iwasaki, Hitoshi ^{[1
]}

Yatoh, Shigeru ^{[1
]}

Suzuki, Hiroaki ^{[1
]}

Aita, Yuichi ^{[1
]}

Han, Song-iee ^{[1
]}

Takeuchi, Yoshinori ^{[1
]}

Yahagi, Naoya ^{[1
]}

Miyamoto, Takafumi ^{[1
,2
]}

Sekiya, Motohiro ^{[1
]}

Nakagawa, Yoshimi ^{[1
,3
]}

Shimano, Hitoshi ^{[1
,3
,4
,5
]}

机构：

[1] Univ Tsukuba, Dept Internal Med Endocrinol & Metab, Fac Med, 1-1-1 Tennodai, Tsukuba, Ibaraki 3058575, Japan

[2] Univ Tsukuba, Transborder Med Res Ctr, 1-1-1 Tennodai, Tsukuba, Ibaraki 3058575, Japan

[3] Univ Tsukuba, Int Inst Integrat Sleep Med WPI IIIS, 1-1-1 Tennodai, Tsukuba, Ibaraki 3058575, Japan

[4] Univ Tsukuba, Tsukuba Adv Res Alliance TARA, Life Sci Ctr Survival Dynam, 1-1-1 Tennodai, Tsukuba, Ibaraki 3058575, Japan

[5] Japan Agcy Med Res & Dev AMED, AMED CREST, Chiyoda Ku, 1-7-1 Ohte Machi, Tokyo 1000004, Japan

来源：

SCIENTIFIC REPORTS | 2019年 / 9卷 / 1期

关键词：

BEIGE FAT; ALCOHOL OXIDATION; ACID OXIDATION; MICE; THERMOGENESIS; CHOLESTEROL; ENERGY; HYPERCHOLESTEROLEMIA; INFLAMMATION; TOLERABILITY;

D O I：

10.1038/s41598-019-41631-1

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Brown adipose tissue (BAT) is an attractive therapeutic target for treating obesity and metabolic diseases. Octacosanol is the main component of policosanol, a mixture of very long chain aliphatic alcohols obtained from plants. The current study aimed to investigate the effect of octacosanol and policosanol on high-fat diet (HFD)-induced obesity. Mice were fed on chow, or HFD, with or without octacosanol or policosanol treatment for four weeks. HFD-fed mice showed significantly higher body weight and body fat compared with chow-fed mice. However, mice fed on HFD treated with octacosanol or policosanol (HFDo/p) showed lower body weight gain, body fat gain, insulin resistance and hepatic lipid content. Lower body fat gain after octacosanol or policosanol was associated with increased BAT activity, reduced expression of genes involved in lipogenesis and cholesterol uptake in the liver, and amelioration of white adipose tissue (WAT) inflammation. Moreover, octacosanol and policosanol significantly increased the expression of Ffar4, a gene encoding polyunsaturated fatty acid receptor, which activates BAT thermogenesis. Together, these results suggest that octacosanol and policosanol ameliorate diet-induced obesity and metabolic disorders by increasing BAT activity and improving hepatic lipid metabolism. Thus, these lipids represent promising therapeutic targets for the prevention and treatment of obesity and obesity-related metabolic disorders.

引用

页数：12

共 63 条

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