Genetic variation in the long terminal repeat associated with the transition of Chinese equine infectious anemia virus from virulence to avirulence

被引：8

作者：

Wei, Lili ^{[1
,2
]}

Fan, Xiujuan ^{[3
]}

Lu, Xiaoling ^{[1
]}

Zhao, Liping ^{[1
]}

Xiang, Wenhua ^{[1
]}

Zhang, Xiaoyan ^{[3
]}

Xue, Fei ^{[1
]}

Shao, Yiming ^{[3
]}

Shen, Rongxian ^{[1
]}

Wang, Xiaojun ^{[1
]}

机构：

[1] Chinese Acad Agr Sci, Harbin Vet Res Inst, Harbin 150001, Peoples R China

[2] NE Agr Univ, Coll Life Sci, Harbin 150030, Peoples R China

[3] China CDC, Natl Ctr AIDS STD Prevent & Control, Beijing 100050, Peoples R China

来源：

VIRUS GENES | 2009年 / 38卷 / 02期

基金：

中国国家自然科学基金;

关键词：

EIAV; LTR; Mutation; Attenuation; AMINO-ACID MUTATIONS; MOLECULAR CLONES; REPLICATION; SEQUENCES; EIAV; SPECIFICITY; ACTIVATION; EXPRESSION; ELEMENT; MOTIFS;

D O I：

10.1007/s11262-008-0317-y

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

A highly virulent strain of equine infectious anemia virus (EIAV) lost its fatal virulence but retained the desired antigens during serial passage over 130 generations in leukocytes in vitro. We compared the long terminal repeat (LTR) sequences of the different generations and found that three stable genetic variations occurred in the transcriptional start site, the initial base of TAR, and the pre-mRNA cleavage site at the R-U5 boundary, respectively. These three mutations happened at the inflexion of virus pathogenicity loss; therefore, the function of these mutations needs to be further addressed.

引用

页码：285 / 288

页数：4

共 6 条

[1] Genetic variation in the long terminal repeat associated with the transition of Chinese equine infectious anemia virus from virulence to avirulence
Lili Wei
Xiujuan Fan
Xiaoling Lu
Liping Zhao
Wenhua Xiang
Xiaoyan Zhang
Fei Xue
Yiming Shao
Rongxian Shen
Xiaojun Wang
Virus Genes, 2009, 38 : 285 - 288
[2] Characterization of Equine Infectious Anemia Virus Long Terminal Repeat Quasispecies In Vitro and In Vivo
Wang, Xue-Feng
Liu, Qiang
Wang, Yu-Hong
Wang, Shuai
Chen, Jie
Lin, Yue-Zhi
Ma, Jian
Zhou, Jian-Hua
Wang, Xiaojun
JOURNAL OF VIROLOGY, 2018, 92 (08)
[3] Genetic variation of envelope gp90 gene of equine infectious anemia virus isolated from an experimentally infected horse
Pang, H
Kong, XG
Sentsui, H
Kono, Y
Sugiura, T
Hasegawa, A
Akashi, H
JOURNAL OF VETERINARY MEDICAL SCIENCE, 1997, 59 (12) : 1089 - 1095
[4] Genetic and biological variation in equine infectious anemia virus rev correlates with variable stages of clinical disease in an experimentally infected pony
Belshan, M
Baccam, P
Oaks, JL
Sponseller, BA
Murphy, SC
Cornette, J
Carpenter, S
VIROLOGY, 2001, 279 (01) : 185 - 200
[5] Genetic characterization by composite sequence analysis of a new pathogenic field strain of equine infectious anemia virus from the 2006 outbreak in Ireland
Quinlivan, Michelle
Cook, Frank
Kenna, Rachel
Callinan, John J.
Cullinane, Ann
JOURNAL OF GENERAL VIROLOGY, 2013, 94 : 612 - 622
[6] Reverse mutation of the virulence-associated S2 gene does not cause an attenuated equine infectious anemia virus strain to revert to pathogenicity
Gao, Xu
Jiang, Cheng-Gang
Wang, Xue-Feng
Lin, Yue-Zhi
Ma, Jian
Han, Xiu-E
Zhao, Li-Ping
Shen, Rong-Xian
Xiang, Wen-Hua
Zhou, Jian-Hua
VIROLOGY, 2013, 443 (02) : 321 - 328

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