Numerical design of a 3D microfluidic systems for bioparticle analysis: electrostatic and dielectrophoretic simulations

Development of in vitro techniques for medical and industrial applications has introduced over the past few years modern devices for detecting and manipulation of biological probes. A major interest is granted for unicellular analysis in order to produce new techniques for cell membrane permeabilization. Microfluidics became an indispensable tool used in cell research and analysis. In this paper, we present a new device for cell manipulation, electroporation and observation. Dielectrophoresis (DEP) is used to transport the cells by dielectroforetic forces (FDEP). The influence of electric field and flow behavior is studied. The simulation results show the influence of flow and dielectrophoretic force on cells migration inside the microfluidics channel.